Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
Specificity
Natural and recombinant Mouse Tumor necrosis factor ligand superfamily member 6
Subcellular Location
Tumor necrosis factor ligand superfamily member 6, soluble form Secreted May be released into the extracellular fluid, probably by cleavage form the cell surface.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FASL);3D-STRUCTURE MODELING