Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.
Specificity
Natural and recombinant Mouse Tumor necrosis factor ligand superfamily member 18
Subcellular Location
Cell membrane Single-pass type II membrane protein