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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Tripartite motif-containing protein 72

SKU : BHE13811671

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3671m
Alternative Names	Mitsugumin-53 ; Mg53 ; Mg53
Categories	Elisa
Function	Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
Specificity	Natural and recombinant Mouse Tripartite motif-containing protein 72
Subcellular Location	Cell membrane sarcolemma Cytoplasmic vesicle membrane Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine.
Detection Range	78-5000pg/mL
Entryname	TRI72_MOUSE
Method Type	Sandwich
Platform	PF13765
Protein Name	Tripartite motif-containing protein 72
Sensitivity	39.9pg/mL
Sequence	50: MSAAPGLLRQ ; ELSCPLCLQL ; FDAPVTAECG ; HSFCRACLIR ; VAGEPAADGT ; 100: VACPCCQAPT ; RPQALSTNLQ ; LSRLVEGLAQ ; VPQGHCEEHL ; DPLSIYCEQD ; 150: RTLVCGVCAS ; LGSHRGHRLL ; PAAEAQARLK ; TQLPQQKMQL ; QEACMRKEKT ; 200: VAVLEHQLVE ; VEETVRQFRG ; AVGEQLGKMR ; MFLAALESSL ; DREAERVRGD ; 250: AGVALRRELS ; SLNSYLEQLR ; QMEKVLEEVA ; DKPQTEFLMK ; FCLVTSRLQK ; 300: ILSESPPPAR ; LDIQLPVISD ; DFKFQVWKKM ; FRALMPALEE ; LTFDPSSAHP ; 350: SLVVSSSGRR ; VECSDQKAPP ; AGEDTRQFDK ; AVAVVAQQLL ; SQGEHYWEVE ; 400: VGDKPRWALG ; VMAADASRRG ; RLHAVPSQGL ; WLLGLRDGKI ; LEAHVEAKEP ; 450: RALRTPERPP ; ARIGLYLSFA ; DGVLAFYDAS ; NPDVLTPIFS ; FHERLPGPVY ; 477: PIFDVCWHDK ; GKNAQPLLLV ; GPEQEQA
Sequence Length	477
String	Q1XH17
Sub Unit	Homooligomer; disulfide-linked. Interacts with DYSF and CAV3.

Uniprot	Q1XH17
Gene Name	Trim72
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:434246
Unigene	Mm.389924

Reference	1. "MG53 nucleates assembly of cell membrane repair machinery." Cai C., Masumiya H., Weisleder N., Matsuda N., Nishi M., Hwang M., Ko J.-K., Lin P., Thornton A., Zhao X., Pan Z., Komazaki S., Brotto M., Takeshima H., Ma J. Nat. Cell Biol.11:56-64(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;SUBUNIT;PHOSPHATIDYLSERINE-BINDING;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;DISULFIDE BOND AT CYS-242;MUTAGENESIS OF CYS-14; CYS-17; CYS-29; CYS-34; CYS-37; CYS-53; CYS-55; CYS-56; CYS-86; CYS-97; CYS-105; CYS-108; CYS-144; CYS-242; CYS-313 AND CYS-456 strain: C57BL/6J. tissue: Skeletal muscle. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Brain. tissue: Jaw. tissue: Limb. 3. "Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes." Masumiya H., Asaumi Y., Nishi M., Minamisawa S., Adachi-Akahane S., Yoshida M., Kangawa K., Ito K., Kagaya Y., Yanagisawa T., Yamazaki T., Ma J., Takeshima H. Channels3:6-11(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 4. "MG53 regulates membrane budding and exocytosis in muscle cells." Cai C., Masumiya H., Weisleder N., Pan Z., Nishi M., Komazaki S., Takeshima H., Ma J. J. Biol. Chem.284:3314-3322(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION 5. "Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin." Cai C., Weisleder N., Ko J.-K., Komazaki S., Sunada Y., Nishi M., Takeshima H., Ma J. J. Biol. Chem.284:15894-15902(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DYSF AND CAV3

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