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ELISA Kit for Mouse Transformation/transcription domain-associated protein

SKU : BHE13811510

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13003m
Alternative Names	Tra1 homolog
Categories	Elisa
Function	Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression.
Specificity	Natural and recombinant Mouse Transformation/transcription domain-associated protein
Subcellular Location	Nucleus
Entryname	TRRAP_MOUSE
Platform	PF02259
Protein Name	Transformation/transcription domain-associated protein
Sequence	50: MTRKFVKRSI ; FLHLLRHQPA ; NAQIGLMEGN ; TFCTTLQPRL ; FTMDLNVVEH ; 100: KVFYTELLNL ; CEAEDSALTK ; LPCYKSLPSL ; VPLRIAALNA ; LAACNYLPQS ; 150: REKIIAALFK ; ALNSTNSELQ ; EAGEACMRKF ; LEGATIEVDQ ; IHTHMRPLLM ; 200: MLGDYRSLTL ; NVVNRLTSVT ; RLFPNSFNDK ; FCDQMMQHLR ; KWMEVVVITH ; 250: KGGQRSDGNE ; MKICSAIINL ; FHLIPAAPQT ; LVKPPLEVVM ; ETERAMLIEA ; 300: GSPFREPLIK ; FLTRHPSQTV ; ELFMMGATLN ; DPQWSRMFMS ; FLKHKDARPL ; 350: RDVLAANPNR ; FITLLLPGGA ; QTAVRPGSSS ; TSNMRLDLQF ; QAIKIISIIV ; 400: KNDDAWLASQ ; HSLVSQLRRV ; WVSETFQERH ; RKENMAATNW ; KEPKLLAFCL ; 450: LNYCKRNYGD ; IELLFQLLRA ; FTGRFLCNMT ; FLKEYMEEEI ; PKNYSIAQKR ; 500: ALFFRFVEFN ; DPNFGDELKA ; KVLQHILNPA ; FLYSFEKGEG ; EQLLGPPNPE ; 550: GDNPESITSV ; FITKVLDPEK ; QADMLDSLRI ; YLLQYATLLV ; EHAPHHIHDN ; 600: NKNRNSKLRR ; LMTFAWPCLL ; SKACVDPACR ; YSGHLLLAHI ; IAKFAIHKKI ; 650: VLQVFHSLLK ; AHAMEARAIV ; RQAMAILTPA ; VPARMEDGHQ ; MLTHWTRKII ; 700: VEEGHTVPQL ; VHILHPIVQH ; FKVYYPVRHH ; LVQHMVSAMQ ; RLGFTPSVTI ; 750: EQRRLAVDLS ; EVVIKWELQR ; IKDQQPDSDM ; DPNSSGEGVN ; SVSIKRGLSV ; 800: DSAQEVKRFR ; AATGAISAVF ; GRSQSLPGAD ; SLLAKPIDKQ ; HTDTVVNFLI ; 850: RVACQVNDNT ; NTAGSPGEVL ; SRRCVNLLKT ; ALRPDMWCKS ; ELKLQWFDKL ; 900: LMTVEQPNQV ; NYGNICTGLE ; VLNFLLTVLQ ; SPAILSSFKP ; LQRGIAACMT ; 950: CGNTKVLRAV ; HSLLSRLMSI ; FPTEPSTSSV ; ASKYEELECL ; YAAVGKVIYE ; 1000: GLTNYEKATS ; ANPSQLFGTL ; MIHKSACCNN ; PSYIDRLISV ; FMRSLQKMVR ; 1050: EHLNPQTASG ; STEATAAGTS ; ELVMLSLDLV ; KTRLAVMSME ; MRKNFIQTIL ; 1100: TSLIEKSPDA ; KILRAVVKIV ; EEWVKNNSPM ; AANQTPTLRE ; KSILLVKMMT ; 1150: YIEKRFPEDL ; ELNAQFLDLV ; NYVYRDEALS ; GSELTAKLEP ; AFLSGLRCAQ ; 1200: PLIRAKFFEV ; FDNSMKRRVY ; ERLLYVTCSQ ; NWEAMGSHFW ; IKQCIELLLA ; 1250: VCEKSTAIGT ; SCQGAMLPSI ; TNVINLADSH ; DRAAFAMVTH ; VKQEPREREN ; 1300: SESKEEDVEI ; DIELAPGDQT ; STPKTKELSE ; KDIGNQLHML ; TNRHDKFLDT ; 1350: LREVKTGALL ; SAFVQLCHIS ; TTLAEKTWVQ ; LFPRLWKILS ; DRQQHALAGE ; 1400: ISPFLCSGSH ; QVQRDCQPSA ; LNCFVEAMSQ ; CVPPIPMRPC ; VLKYLGKTHN ; 1450: LWFRSTLMLE ; HQAFEKGLSL ; PIKPKQTTEF ; YEQESITPPQ ; QEILDSLAEL ; 1500: YSLLQEEDMW ; AGLWQKRCKF ; SETATAIAYE ; QHGFFEQAQE ; SYEKAMDKAK ; 1550: KEHERSNASP ; AIFPEYQLWE ; DHWIRCSKEL ; NQWEALTEFG ; QSKGHINPYL ; 1600: VLECAWRVSN ; WTAMKEALVQ ; VEVSCPKEMA ; WKVNMYRGYL ; AICHPEEQQL ; 1650: SFIERLVEMA ; SSLAIREWRR ; LPHVVSHVHT ; PLLQAAQQII ; ELQEAAQINA ; 1700: GLQPTNLGRN ; NSLHDMKTVV ; KTWRNRLPIV ; SDDLSHWSSV ; FMWRQHHYQA ; 1750: IVTAYENSSH ; HDPSSNNAML ; GVHASASAII ; QYGKIARKQG ; LVNVALDILS ; 1800: RIHTIPTVPI ; VDCFQKIRQQ ; VKCYLQLAGV ; MGKNECMQGL ; EVIESTNLKY ; 1850: FTKEMTAEFY ; ALKGMFLAQI ; NKSEEANKAF ; SAAVQMHDVL ; VKAWAMWGDY ; 1900: LESIFVKERQ ; LHLGVSAITC ; YLHACRHQNE ; SKSRKYLAKV ; LWLLSFDDDK ; 1950: NTLADAVDKY ; CIGVPPIQWL ; AWIPQLLTCL ; VGSEGKLLLN ; LISQVGRVYP ; 2000: QAVYFPIRTL ; YLTLKIEQRE ; RYKSDSGQQQ ; PSSAGNQSHS ; ASDPGPIRAT ; 2050: APMWRCSRIM ; HMQRELHPTL ; LSSLEGIVDQ ; MVWFRENWHE ; EVLRQLQQGL ; 2100: AKCYSVAFEK ; SGAVSDAKIT ; PHTLNFVKKL ; VSTFGVGLEN ; VSNVSTMFSS ; 2150: AASESLARRA ; QATAQDPVFQ ; KLKGQFTTDF ; DFSVPGSMKL ; HNLISKLKKW ; 2200: IKILEAKTKQ ; LPKFFLIEEK ; CRFLSNFSAQ ; TAEVEIPGEF ; LMPKPTHYYI ; 2250: KIARFMPRVE ; IVQKHNTAAR ; RLHIRGHNGK ; IYPYLVMNDA ; CLTESRREER ; 2300: VLQLLRLLNP ; CLEKRKETTK ; RHLFFTVPRV ; VAVSPQMRLV ; EDNPSSLSLV ; 2350: EIYKQRCAKK ; GIEHDNPISR ; YYDRLATVQA ; RGTQASHQVL ; RDILKEVQSN ; 2400: MVPRSMLKEW ; ALHTFPNATD ; YWTFRKMFTI ; QLALIGFAEF ; VLHLNRLNPE ; 2450: MLQIAQDTGK ; LNVAYFRFDI ; NDATGDLDAN ; RPVPFRLTPN ; ISEFLTTIGV ; 2500: SGPLTASMIA ; VARCFAQPNF ; KVDGVLKTVL ; RDEIIAWHKK ; TQEDTSSPLS ; 2550: AAGQPENMDS ; QQLVSLVQKA ; VTAIMTRLHN ; LAQFDGGESK ; VNTLVAAANS ; 2565: LDNLCRMDPA ; WHPWL
Sequence Length	2565
String	Q80YV3
Sub Unit	Interacts with MYC, E2F1 and E2F4 transcription factors. Interacts directly with p53/TP53. Interacts with GCN5L2. Component of various HAT complexes. Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of the STAGA complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitinylation composed of ATXN7L3, ENY2 and USP22. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes. Interacts with NPAT (By similarity). Interaction with TELO2 AND TTI1.

Uniprot	Q80YV3
Gene Name	Trrap
Immunogen Species	Mus musculus (Mouse)
Unigene	Mm.273570

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