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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Transcription factor RelB

SKU : BHE13809118

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1732m
Categories	Elisa
Function	NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.
Specificity	Natural and recombinant Mouse Transcription factor RelB
Subcellular Location	Nucleus Cytoplasm cytoskeleton centrosome Co-localizes with NEK6 in the centrosome.
Detection Range	0.156-10ng/mL
Entryname	RELB_MOUSE
Method Type	Sandwich
Platform	PF00554
Protein Name	Transcription factor RelB
Sensitivity	0.081ng/mL
Sequence	50: MPSRRAARES ; APELGALGSS ; DLSSLSLTVS ; RTTDELEIID ; EYIKENGFGL ; 100: DGTQLSEMPR ; LVPRGPASLS ; SVTLGPAAPP ; PPATPSWSCT ; LGRLVSPGPC ; 150: PRPYLVITEQ ; PKQRGMRFRY ; ECEGRSAGSI ; LGESSTEASK ; TLPAIELRDC ; 200: GGLREVEVTA ; CLVWKDWPHR ; VHPHSLVGKD ; CTDGVCRVRL ; RPHVSPRHSF ; 250: NNLGIQCVRK ; KEIEAAIERK ; IQLGIDPYNA ; GSLKNHQEVD ; MNVVRICFQA ; 300: SYRDQQGHLH ; RMDPILSEPV ; YDKKSTNTSE ; LRICRINKES ; GPCTGGEELY ; 350: LLCDKVQKED ; ISVVFSTASW ; EGRADFSQAD ; VHRQIAIVFK ; TPPYEDLEIS ; 400: EPVTVNVFLQ ; RLTDGVCSEP ; LPFTYLPRDH ; DSYGVDKKRK ; RGLPDVLGEL ; 450: SSSDPHGIES ; KRRKKKPVFL ; DHFLPGHSSG ; LFLPPSALQP ; ADSDFFPASI ; 500: SLPGLEPPGG ; PDLLDDGFAY ; DPSAPTLFTM ; LDLLPPAPPL ; ASAVVGSGGA ; 550: GATVVESSGP ; EPLSLDSFAA ; PGPGDVGTAS ; LVGSNMFPNQ ; YREAAFGGGL ; 558: LSPGPEAT
Sequence Length	558
String	Q04863
Sub Unit	Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex (By similarity). Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID.

Uniprot	Q04863
Gene Name	Relb
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:19698
Unigene	Mm.1741

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809118	E1732m	96T	$776		Add to Cart

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