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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Transcription factor 7-like 2

SKU : BHE13808899

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E5449m
Alternative Names	HMG box transcription factor 4 ; T-cell-specific transcription factor 4 ; T-cell factor 4 ; Tcf4
Categories	Elisa
Function	Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Specificity	Natural and recombinant Mouse Transcription factor 7-like 2
Subcellular Location	Nucleus PML body Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.
Detection Range	62.5-4000pg/mL
Entryname	TF7L2_MOUSE
Method Type	Sandwich
Platform	PF08347
Protein Name	Transcription factor 7-like 2
Sensitivity	31.25pg/mL
Sequence	50: MPQLNGGGGD ; DLGANDELIS ; FKDEGEQEEK ; NSENSSAERD ; LADVKSSLVN ; 100: ESETNQDSSS ; DSEAERRPPP ; RSESFRDKSR ; ESLEEAAKRQ ; DGGLFKGPPY ; 150: PGYPFIMIPD ; LTSPYLPNGS ; LSPTARTYLQ ; MKWPLLDVQA ; GSLQSRQTLK ; 200: DARSPSPAHI ; VSNKVPVVQH ; PHHVHPLTPL ; ITYSNEHFTP ; GNPPPHLPAD ; 250: VDPKTGIPRP ; PHPPDISPYY ; PLSPGTVGQI ; PHPLGWLVPQ ; QGQPVYPITT ; 300: GGFRHPYPTA ; LTVNASMSRF ; PPHMVPPHHT ; LHTTGIPHPA ; IVTPTVKQES ; 350: SQSDVGSLHS ; SKHQDSKKEE ; EKKKPHIKKP ; LNAFMLYMKE ; MRAKVVAECT ; 400: LKESAAINQI ; LGRRWHALSR ; EEQAKYYELA ; RKERQLHMQL ; YPGWSARDNY ; 450: GKKKKRKRDK ; QPGETNEHSE ; CFLNPCLSLP ; PITDLSAPKK ; CRARFGLDQQ ; 459: NNWCGPCSL
Sequence Length	459
String	Q924A0
Sub Unit	Interacts with TGFB1I1. Interacts with CTNNB1 (via the armadillo repeat); forms stable transcription complex. Interacts with EP300. Interacts with NLK. Interacts with CCDC85B (probably through the HMG box); prevents interaction with CTNNB1. Interacts with MAD2L2; prevents TCF7L2/TCF4 binding to promoters, negatively modulating its transcriptional activity (By similarity). Interacts with TNIK.

Uniprot	Q924A0
Gene Name	Tcf7l2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:21416
Unigene	Mm.139815

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808899	E5449m	96T	$776		Add to Cart

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