Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection.
Specificity
Natural and recombinant Mouse Toll-like receptor 9
Subcellular Location
Endoplasmic reticulum membrane Single-pass type I membrane protein Endosome Lysosome Cytoplasmic vesicle phagosome Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (By similarity). Interacts with CNPY3. Interacts (via transmembrane domain) with UNC93B1.