Nuclear receptor subfamily 1 group A member 1 ; c-erbA-1 ; c-erbA-alpha ; C-erba-alpha ; Nr1a1
Categories
Elisa
Function
Nuclear hormone receptor. High affinity receptor for triiodothyronine. Isoform Alpha-deltaE6 does not bind DNA, inhibits the activity of isoform Alpha-1, and stimulates myoblast differentiation.
Specificity
Natural and recombinant Mouse Thyroid hormone receptor alpha
Subcellular Location
Isoform Alpha-deltaE6 Cytoplasm Sequesters isoform Alpha-1 into this compartment.
Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with AKAP13 (By similarity). Interacts with C1D.