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ELISA Kit for Mouse Sortilin

SKU : BHE13810514

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9893m
Alternative Names	Neurotensin receptor 3 ; NTR3
Categories	Elisa
Function	Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
Specificity	Natural and recombinant Mouse Sortilin
Subcellular Location	Membrane Single-pass type I membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein Endosome membrane Single-pass type I membrane protein Golgi apparatus Golgi stack membrane Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein Nucleus membrane Single-pass type I membrane protein Cell membrane Single-pass type I membrane protein Extracellular side Lysosome membrane Single-pass type I membrane protein Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes is enhanced by insulin.
Entryname	SORT_MOUSE
Platform	PF02012
Protein Name	Sortilin
Sequence	50: MERPRGAADG ; LLRWPLGLLL ; LLQLLPPAAV ; GQDRLDAPPP ; PAPPLLRWAG ; 100: PVGVSWGLRA ; AAPGGPVPRA ; GRWRRGAPAE ; DQDCGRLPDF ; IAKLTNNTHQ ; 150: HVFDDLSGSV ; SLSWVGDSTG ; VILVLTTFQV ; PLVIVSFGQS ; KLYRSEDYGK ; 200: NFKDITNLIN ; NTFIRTEFGM ; AIGPENSGKV ; ILTAEVSGGS ; RGGRVFRSSD ; 250: FAKNFVQTDL ; PFHPLTQMMY ; SPQNSDYLLA ; LSTENGLWVS ; KNFGEKWEEI ; 300: HKAVCLAKWG ; PNNIIFFTTH ; VNGSCKADLG ; ALELWRTSDL ; GKTFKTIGVK ; 350: IYSFGLGGRF ; LFASVMADKD ; TTRRIHVSTD ; QGDTWSMAQL ; PSVGQEQFYS ; 400: ILAANEDMVF ; MHVDEPGDTG ; FGTIFTSDDR ; GIVYSKSLDR ; HLYTTTGGET ; 450: DFTNVTSLRG ; VYITSTLSED ; NSIQSMITFD ; QGGRWEHLRK ; PENSKCDATA ; 500: KNKNECSLHI ; HASYSISQKL ; NVPMAPLSEP ; NAVGIVIAHG ; SVGDAISVMV ; 550: PDVYISDDGG ; YSWAKMLEGP ; HYYTILDSGG ; IIVAIEHSNR ; PINVIKFSTD ; 600: EGQCWQSYVF ; TQEPIYFTGL ; ASEPGARSMN ; ISIWGFTESF ; ITRQWVSYTV ; 650: DFKDILERNC ; EEDDYTTWLA ; HSTDPGDYKD ; GCILGYKEQF ; LRLRKSSVCQ ; 700: NGRDYVVAKQ ; PSVCPCSLED ; FLCDFGYFRP ; ENASECVEQP ; ELKGHELEFC ; 750: LYGKEEHLTT ; NGYRKIPGDK ; CQGGMNPARE ; VKDLKKKCTS ; NFLNPTKQNS ; 800: KSNSVPIILA ; IVGLMLVTVV ; AGVLIVKKYV ; CGGRFLVHRY ; SVLQQHAEAD ; 825: GVEALDSTSH ; AKSGYHDDSD ; EDLLE
Sequence Length	825
String	Q6PHU5
Sub Unit	Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP, NTS and GM2A. Forms a complex with NGFR which binds specifically to the precursor forms of NGFB (proNGFB) and BDNF (proBDNF) (By similarity). Interacts with LPL, PSAP and SLC2A4.

Uniprot	Q6PHU5
Gene Name	Sort1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:20661
Unigene	Mm.157119

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810514	E9893m	96T	$776		Add to Cart

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