High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
Specificity
Natural and recombinant Mouse Signaling lymphocytic activation molecule
Subcellular Location
Cell membrane Single-pass type I membrane protein Present on the surface of B-cells and T-cells.
Interacts with INPP5D/SHIP1 (By similarity). Interacts (via cytoplasmic domain) with SH2D1A. Interacts (upon tyrosine phosphorylation with) PTPN11, but not with SHP-1.
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3.
"Genomic organization of murine Slam." Wu C., Wang N., Sayos J., Terhorst C. Submitted (1999-06) to the EMBL/GenBank/DDBJ databases
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