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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Signal transducer and activator of transcription 3

SKU : BHE13810139

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1743m
Alternative Names	Acute-phase response factor ; Aprf
Categories	Elisa
Function	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.
Specificity	Natural and recombinant Mouse Signal transducer and activator of transcription 3
Subcellular Location	Cytoplasm Nucleus Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 (By similarity). Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation.
Detection Range	0.312-20ng/mL
Entryname	STAT3_MOUSE
Method Type	Sandwich
Platform	PF00017
Protein Name	Signal transducer and activator of transcription 3
Sensitivity	0.171ng/mL
Sequence	50: MAQWNQLQQL ; DTRYLEQLHQ ; LYSDSFPMEL ; RQFLAPWIES ; QDWAYAASKE ; 100: SHATLVFHNL ; LGEIDQQYSR ; FLQESNVLYQ ; HNLRRIKQFL ; QSRYLEKPME ; 150: IARIVARCLW ; EESRLLQTAA ; TAAQQGGQAN ; HPTAAVVTEK ; QQMLEQHLQD ; 200: VRKRVQDLEQ ; KMKVVENLQD ; DFDFNYKTLK ; SQGDMQDLNG ; NNQSVTRQKM ; 250: QQLEQMLTAL ; DQMRRSIVSE ; LAGLLSAMEY ; VQKTLTDEEL ; ADWKRRQQIA ; 300: CIGGPPNICL ; DRLENWITSL ; AESQLQTRQQ ; IKKLEELQQK ; VSYKGDPIVQ ; 350: HRPMLEERIV ; ELFRNLMKSA ; FVVERQPCMP ; MHPDRPLVIK ; TGVQFTTKVR ; 400: LLVKFPELNY ; QLKIKVCIDK ; DSGDVAALRG ; SRKFNILGTN ; TKVMNMEESN ; 450: NGSLSAEFKH ; LTLREQRCGN ; GGRANCDASL ; IVTEELHLIT ; FETEVYHQGL ; 500: KIDLETHSLP ; VVVISNICQM ; PNAWASILWY ; NMLTNNPKNV ; NFFTKPPIGT ; 550: WDQVAEVLSW ; QFSSTTKRGL ; SIEQLTTLAE ; KLLGPGVNYS ; GCQITWAKFC ; 600: KENMAGKGFS ; FWVWLDNIID ; LVKKYILALW ; NEGYIMGFIS ; KERERAILST ; 650: KPPGTFLLRF ; SESSKEGGVT ; FTWVEKDISG ; KTQIQSVEPY ; TKQQLNNMSF ; 700: AEIIMGYKIM ; DATNILVSPL ; VYLYPDIPKE ; EAFGKYCRPE ; SQEHPEADPG ; 750: SAAPYLKTKF ; ICVTPTTCSN ; TIDLPMSPRT ; LDSLMQFGNN ; GEGAEPSAGG ; 770: QFESLTFDMD ; LTSECATSPM ;
Sequence Length	770
String	P42227
Sub Unit	Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import. Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation. Interacts with ARL2BP; interaction is enhanced with ARL2. Binds to CDK9 when activated and nuclear (By similarity). Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression. Interacts with NEK6. Interacts with BMX.

Uniprot	P42227
Gene Name	Stat3
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:20848
Unigene	Mm.249934

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810139	E1743m	96T	$776		Add to Cart

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