Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis.
Specificity
Natural and recombinant Mouse Signal-induced proliferation-associated 1-like protein 1
Subcellular Location
Cytoplasm cytoskeleton Cell junction synapse postsynaptic cell membrane postsynaptic density Cell junction synapse synaptosome Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons.
Interacts with DLG4, PDLIM5, PDLIM7 and PROSAPIP1. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases.