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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Serine/threonine-protein phosphatase 2A activator

SKU : BHE13809410

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10699m
Alternative Names	PP2A ; subunit B' ; PR53 isoform ; Phosphotyrosyl phosphatase activator ; PTPA ; Serine/threonine-protein phosphatase 2A regulatory subunit 4 ; Serine/threonine-protein phosphatase 2A regulatory subunit B' ; Ptpa
Categories	Elisa
Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activty of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
Specificity	Natural and recombinant Mouse Serine/threonine-protein phosphatase 2A activator
Subcellular Location	Cytoplasm Nucleus
Entryname	PTPA_MOUSE
Platform	PF03095
Protein Name	Serine/threonine-protein phosphatase 2A activator
Sequence	50: MAEGERQPPP ; DSSEETPPTT ; QNFIIPKKEI ; HTVPDMGKWK ; RSQAYADYIG ; 100: FILTLNEGVK ; GKKLTFDYKV ; SEAIEKLVAL ; LDTLDRWIDE ; TPPVDQPSRF ; 150: GNKAYRTWYA ; KLDQEAENLV ; ATVVPTHLAA ; AVPEVAVYLK ; EAVGNSTRID ; 200: YGTGHEAAFA ; AFLCCLCKIG ; VLRVDDQVAI ; VFKVFDRYLE ; VMRKLQKTYR ; 250: MEPAGSQGVW ; GLDDFQFLPF ; IWGSSQLIDH ; PHLEPRHFVD ; EKAVSENHKD ; 300: YMFLQCILFI ; TEMKTGPFAE ; HSNQLWNISA ; VPSWSKVNQG ; LIRMYKAECL ; 323: EKFPVIQHFK ; FGSLLPIHPV ; TSG
Sequence Length	323
String	P58389
Sub Unit	Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A) (By similarity). Interacts with PPP2CB.

Uniprot	P58389
Gene Name	Ppp2r4
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:110854
Unigene	Mm.275393

Reference	1. "Characterization of the mouse homolog of the human phosphotyrosyl phosphatase activator, PTPA." David J., Yang X., Hashimoto K., Ramotar D. Submitted (2001-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/6. tissue: Brain. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: C3H/He. strain: FVB/N. tissue: Mammary gland. tissue: Osteoblast. 3. "A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo." Fellner T., Lackner D.H., Hombauer H., Piribauer P., Mudrak I., Zaragoza K., Juno C., Ogris E. Genes Dev.17:2138-2150(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PPP2CB

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809410	E10699m	96T	$776		Add to Cart

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