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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Serine/threonine-protein kinase TAO2

SKU : BHE13810830

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2239m
Alternative Names	Thousand and one amino acid protein 2 ; Kiaa0881
Categories	Elisa
Function	Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation.
Specificity	Natural and recombinant Mouse Serine/threonine-protein kinase TAO2
Subcellular Location	Isoform 2 Cell projection dendrite In dendrites, colocalizes with PCDH8.
Detection Range	0.156-10ng/mL
Entryname	TAOK2_MOUSE
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase TAO2
Sensitivity	0.085ng/mL
Sequence	50: MPAGGRAGSL ; KDPDVAELFF ; KDDPEKLFSD ; LREIGHGSFG ; AVYFARDVRN ; 100: SEVVAIKKMS ; YSGKQSNEKW ; QDIIKEVRFL ; QKLRHPNTIQ ; YRGCYLREHT ; 150: AWLVMEYCLG ; SASDLLEVHK ; KPLQEVEIAA ; VTHGALQGLA ; YLHSHNMIHR ; 200: DVKAGNILLS ; EPGLVKLGDF ; GSASIMAPAN ; SFVGTPYWMA ; PEVILAMDEG ; 250: QYDGKVDVWS ; LGITCIELAE ; RKPPLFNMNA ; MSALYHIAQN ; ESPALQSGHW ; 300: SEYFRNFVDS ; CLQKIPQDRP ; TSEVLLKHRF ; VLRERPPTVI ; MDLIQRTKDA ; 350: VRELDNLQYR ; KMKKILFQEA ; PNGPGAEAPE ; EEELTPCSQE ; AEPYTHRAGT ; 400: LTSLESSHSV ; PSMSISASSQ ; SSSVNSLADA ; SDNEEEEEEE ; EEEEEEEEEE ; 450: GPESREMAMM ; QEGEHTVTSH ; SSIIHRLPGS ; DNLYDDPYQP ; EMTPGPLQPP ; 500: AAPPTSTSSS ; ARRRAYCRNR ; DHFATIRTAS ; LVSRQIQEHE ; QDSALREQLS ; 550: GYKRMRRQHQ ; KQLLALESRL ; RGEREEHSGR ; LQRELEAQRA ; GFGTEAEKLA ; 600: RRHQAIGEKE ; ARAAQAEERK ; FQQHILGQQK ; KELAALLEAQ ; KRTYKLRKEQ ; 650: LKEELQENPS ; TPKREKAEWL ; LRQKEQLQQC ; QAEEEAGLLR ; RQRQYFELQC ; 700: RQYKRKMLLA ; RHSLDQDLLR ; EDLNKKQTQK ; DLECALLLRQ ; HEATRELELR ; 750: QLQAVQRTRA ; ELTRLQHQTE ; LGNQLEYNKR ; REQELRQKHA ; AQVRQQPKSL ; 800: KVRAGQLPMG ; LPATGALGPL ; STGTPSEEQP ; CSSGQEAILD ; QRMLGEEEEA ; 850: VPERRILGKE ; GTTLEPEEQR ; ILGEEMGTFS ; SSPQKHRSLA ; NEEDWDISEE ; 900: MKEIRVPSLA ; SQERNIIGQE ; EAAAWSLWEK ; EGGNLVDVEF ; KLGWVQGPVL ; 950: TPVPEEEEEE ; EEEGGAPIGT ; HRDPGDGCPS ; PDIPPEPPPS ; HLRQYPTSQL ; 1000: PGLLSHGLLA ; GLSFAVGSSS ; GLLPLLLLLL ; LPLLAAQGGG ; GLQAALLALE ; 1050: VGLVGLGASY ; LFLCTALHLP ; PGLFLLLAQG ; TALLAVLSLS ; WRRGLMGVPL ; 1100: GLGAAWLLAW ; PSLALPLAAM ; AAGGKWVRQQ ; GPQMRRGISR ; LWLRILLRLS ; 1150: PMVFRALQGC ; GAVGDRGLFA ; LYPKTNKNGF ; RSRLPVPWPR ; QGNPRTTQHP ; 1200: LAQLTRVWAV ; CKGWNWRLAR ; ASHRLASCLP ; PWAVHILASW ; GLLKGERPSR ; 1240: IPRLLPRSQR ; RLGLSASRQL ; PPGTVAGRRS ; QTRRTLPPWR ;
Sequence Length	1240
String	Q6ZQ29
Sub Unit	Interacts with MAP2K3 and MAP2K6 (By similarity). Self-associates. Interacts with tubulins. Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation (By similarity). Isoform 2 interacts with PCDH8; this complex may also include CDH2.

Uniprot	Q6ZQ29
Gene Name	Taok2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:381921
Unigene	Mm.259634

Reference	1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2) tissue: Embryonic tail. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) strain: C57BL/6. strain: Czech II. tissue: Brain. tissue: Lung.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810830	E2239m	96T	$776		Add to Cart

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