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ELISA Kit for Mouse Serine/threonine-protein kinase SMG1

SKU : BHE13810309

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3517m
Alternative Names	Kiaa0421
Categories	Elisa
Function	Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.
Specificity	Natural and recombinant Mouse Serine/threonine-protein kinase SMG1
Subcellular Location	Nucleus Cytoplasm
Entryname	SMG1_MOUSE
Platform	PF02260
Protein Name	Serine/threonine-protein kinase SMG1
Sequence	50: MSRRAPGSRL ; SSGGGGTKYP ; RSWNDWQPRT ; DSASADPDTL ; KYSSSRDRGV ; 100: SSSYGLQPSN ; SAVVSRQRHD ; DTRGHADIQN ; DEKGGYSVNG ; GSGENTYGRK ; 150: SLGQELRINN ; VTSPEFTSVQ ; HGSRALATKD ; MRKSQERSMS ; YSDESRLSNL ; 200: LRRITREDDR ; DRRLATVKQL ; KEFIQQPENK ; LVLVKQLDNI ; LAAVHDVLNE ; 250: SSKLLQELRQ ; EGACCLGLLC ; ASLSYEAEKI ; FKWIFSKFSS ; SAKDEVKLLY ; 300: LCATYRALET ; VGEKKAFSSV ; MQLVMTSLQS ; ILENVDTPEL ; LCKCVKCILL ; 350: VARCYPHIFS ; TNFRDTVDIL ; VGWHIDHTQK ; PSLTQQVSGW ; LQSLEPFWVA ; 400: DLAFSTTLLG ; QFLEDMEAYA ; EDLSHVASGE ; SVDEDVPPPS ; VSLPKLAALL ; 450: RVFSTVVRSI ; GERFSPIRGP ; PITEAYVTDV ; LYRVMRCVTA ; ANQVFFSEAV ; 500: LTAANECVGV ; LLGSLDPSMT ; IHCDMVITYG ; LDQLENCQTC ; GTDYIISVLN ; 550: LLTLIVEQIN ; TKLPSSFVEK ; LFIPSSKLLF ; LRYHKEKEVV ; AVAHAVYQAV ; 600: LSLKNIPVLE ; TAYKLILGEM ; TCALNNLLHS ; LQLPDACSEI ; KHEAFQNHVF ; 650: NIDNANFVVI ; FDLSALTTIG ; NAKNSLIGMW ; ALSPTVFALL ; SKNLMIVHSD ; 700: LAVHFPAIQY ; AVLYTLYSHC ; TRHDHFISSS ; LSSSSPSLFD ; GAVISTVTTA ; 750: TKKHFSIILN ; LLGILLKKDN ; LNQDTRKLLM ; TWALEVAVLM ; KKSETYAPLF ; 800: SLPSFHKFSK ; GLLANTLVED ; VNICLQACSS ; LHALSSSLPD ; DLLQRCVDVC ; 850: RVQLVHSGTR ; IRQAFGKLLK ; SIPLDVVLSN ; NNHTEIQEIS ; LALRSHMSKA ; 900: PSNTFHPQDF ; SDVISFILYG ; NSHRTGKDNW ; LERLFYSCQR ; LDKRDQSTIP ; 950: RNLLKTDAVL ; WQWAIWEAAQ ; FTVLSKLRTP ; LGRAQDTFQT ; IEGIIRSLAA ; 1000: HTLNPDQDVS ; QWTTADNDEG ; HGSNQLRLVL ; LLQYLENLEK ; LMYNAYEGCA ; 1050: NALTSPPKVI ; RTFFYTNRQT ; CQDWLTRIRL ; SIMRVGLLAG ; QPAVTVRHGF ; 1100: DLLTEMKTNS ; LTQGSELEVT ; IMMVVEALCE ; LHCPEAIQGI ; AVWSSSAVGK ; 1150: NLLWINSVAQ ; QAEGRFEKAS ; VEYQEHLCAM ; TGVDCCISSF ; DKSVLTLANA ; 1200: GRNSASPKHS ; LNGESRKTVL ; SKSIDSSPEV ; ISYLGNKACE ; CYISIADWAA ; 1250: VQEWQNAVHD ; LKKNSSSTSL ; NLKADFNYIK ; SLSSFESGEF ; VECTEQLELL ; 1300: PGENINLLAG ; GSKEKIDMKK ; LLPNMLSPDP ; RELQKSIEVQ ; LLRSSVFLAT ; 1350: ALNHMEQDQK ; WQSLTENVVK ; YLKQTSRIAI ; GPLRLSTLTV ; SQSLPVLSTL ; 1400: QLYCSSALEN ; TVSNRLSTED ; CLIPLFSDAL ; RSCKQHDVRP ; WMQALRYTMY ; 1450: QNQLLEKIKE ; QTVPIRSHLM ; ELGLTAAKFA ; RKRGNVSLAT ; RLLAQCSEVQ ; 1500: LGKTTTAQDL ; VQHFKKLSTQ ; GQVDEKWGPE ; LDIEKTKLLY ; TAGQSTHAME ; 1550: MLSSCAISFC ; KSAKAEYAVA ; KSILTLAKWV ; QAEWKEISGQ ; LRQVYRAQQQ ; 1600: QNLSGLSTLS ; RNILALIELP ; SANTVGEEHP ; RIESESTVHI ; GVGEPDFILG ; 1650: QLYHLSSVQA ; PEVAKSWAAL ; ASWAYRWGRK ; VVDNASQGEG ; VRLLPREKSE ; 1700: VQNLLPDTIT ; EEEKERIYGI ; LGQAVCRPAG ; IQDEDITLQI ; TESEDNEDDD ; 1750: MVDVIWRQLI ; SSCPWLSELD ; ENATEGVIKV ; WRKVVDRIFS ; LYKLSCSAYF ; 1800: TFLKLNAGQV ; LLDEDDPRLH ; LSHRAEQSTD ; DVIVMATLRL ; LRLLVKHAGE ; 1850: LRQYLEHGLE ; TTPTAPWRGI ; IPQLFSRLNH ; PEVYVRQSIC ; NLLCRVAQDS ; 1900: PHLILYPAIV ; GTISLSSESQ ; ASGNKYSSAI ; PTLLGNIQGE ; ELLVSECEGG ; 1950: SPPASQDSNK ; DEPKSGLNED ; QAMMQDCYSK ; IVDKLSSANP ; TMVLQVQMLV ; 2000: AELRRVTVLW ; DELWLGVLLQ ; QHMYVLRRIQ ; QLEDEVKRVQ ; NNNTLRKEEK ; 2050: IAIMREKHTA ; LMKPIVFALE ; HVRSITAAPA ; ETPHEKWFQD ; NYGDAIDNAL ; 2100: EKLKTPSNPA ; KPGSSWIPFK ; EIMLSLQQRA ; QKRASYILRL ; DEISPWLAAM ; 2150: TNTEIALPGE ; VSARDTVTIH ; SVGGTITILP ; TKTKPKKLLF ; LGSDGKSYPY ; 2200: LFKGLEDLHL ; DERIMQFLSI ; VNTMFATINR ; QETPRFHARH ; YSVTPLGTRS ; 2250: GLIQWVDGAT ; PLFGLYKRWQ ; QREAALQAQK ; AQDSYQTPQN ; PSIVPRPSEL ; 2300: YYSKIGPALK ; TVGLSLDVSR ; RDWPLHVMKA ; VLEELMEATP ; PNLLAKELWS ; 2350: SCTTPDEWWR ; VTQSYARSTA ; VMSMVGYIIG ; LGDRHLDNVL ; IDMTTGEVVH ; 2400: IDYNVCFEKG ; KSLRVPEKVP ; FRMTQNIETA ; LGVTGVEGVF ; RLSCEQVLHI ; 2450: MRRGRETLLT ; LLEAFVYDPL ; VDWTAGGEAG ; FAGAVYGGGG ; QQAESKQSKR ; 2500: EMEREITRSL ; FSSRVAEIKV ; NWFKNRDEML ; VVLPKLDSSL ; DEYLSLQEQL ; 2550: TDVEKLQGKL ; LEEIEFLEGA ; EGVDHPSHTL ; QHRYSEHTQL ; QTQQRAVQEA ; 2600: IQVKLNEFEQ ; WITHYQAAFN ; NLEATQLASL ; LQEISTQMDL ; GPPSYVPATA ; 2650: FLQNAGQAHL ; ISQCEQLEGE ; VGALLQQRRS ; VLRGCLEQLH ; HYATVALQYP ; 2700: KAIFQKHRIE ; QWKAWMEELI ; CNTTVERCQE ; LYRKYEMQYA ; PQPPPTVCQF ; 2750: ITATEMTLQR ; YAADINSRLI ; RQVERLKQEA ; VTVPVCEDQL ; KEIERCIKVF ; 2800: LHENGEEGSL ; SLASVIISAL ; CTLTRRNLMM ; EGAASSAGEQ ; LVDLTSRDGA ; 2850: WFLEELCSMS ; GNVTCLVQLL ; KQCHLVPQDL ; DIPNPVEASE ; AVHLANGVYT ; 2900: SLQELNSNFR ; QIIFPEALRC ; LMKGECTLES ; MLHELDSLIE ; QTTDGVPLQT ; 2950: LVESLQAYLR ; NTAMGLEEET ; HAHYIDVARM ; LHAQYGELIQ ; PRNGSVDETP ; 3000: KMSAGQMLLV ; AFDGMFAQVE ; TAFGLLVEKL ; NKMEIPVAWR ; KIDIIREARS ; 3050: TQVNFFDDDN ; HRQVLEEIFF ; LKRLQTIKEF ; FRLCGTFSKT ; LSGSSSLEDQ ; 3100: NTVNGPVQIV ; NVKTLFRNSC ; FSEDQMAKPI ; KAFTADFVRQ ; LLIGLPNQAL ; 3150: GLTLCSFISA ; LGVDIIAQVE ; AKDFGAESKV ; SVDDLCKKAV ; EHNIQVGKFS ; 3200: QLVMNRATVL ; ASSYDTAWKK ; HDLVRRLETS ; ISSCKTSLQR ; VQLHIAMFQW ; 3250: QHEDLLISRP ; QAMSVTPPRS ; AILTSMKKKL ; HALSQIETSI ; GTVQEKLAAL ; 3300: EASIEQRLKW ; AGGANPALAP ; VLQDFEATIA ; ERRNLVLKES ; QRANQVTFLC ; 3350: SNIIHFESLR ; TRTAEALSLD ; AALFELIKRC ; QQMCSFASQF ; NSSVSELELR ; 3400: LLQRVDTTLE ; HPIGSSEWLL ; SAHKQLTQDM ; STQRAVQTEK ; EQQIETVCET ; 3450: IQSLVDSVKT ; VLTGHNRQLG ; DVKHLLKAMA ; KDEEAALADA ; EDIPYESSVR ; 3500: QFLAEYKSWQ ; DNIQTVLFTL ; VQAMGQVRSQ ; EHVEMLQEIT ; PTLKELKTQS ; 3550: QSIYNNLVSF ; ASPLVTDAAN ; ECSSPTSSAT ; YQPSFAAAVR ; SNTGQKTQPD ; 3600: VMSQNAKKLI ; QKNLATSADT ; PPSTIPGTGK ; SIACSPKKAV ; RDPKTGKAVQ ; 3650: ERNSYAVSVW ; KRVKAKLEGR ; DVDPNRRMSV ; AEQVDYVIKE ; ATNLDNLAQL ; 3658: YEGWTAWV
Sequence Length	3658
String	Q8BKX6
Sub Unit	Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with PRKCI. Interacts with TELO2 and TTI1. Interacts with RUVBL1 and RUVBL2.

Uniprot	Q8BKX6
Gene Name	Smg1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:233789
Unigene	Mm.309053

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