Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Specificity
Natural and recombinant Mouse Serine/threonine-protein kinase SIK2
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF LYS-49
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;PHOSPHORYLATION AT THR-175 AND SER-587;MUTAGENESIS OF LYS-49 AND THR-175
Reviews of ELISA Kit for Mouse Serine/threonine-protein kinase SIK2