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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Serine/threonine-protein kinase PINK1, mitochondrial

SKU : BHE13808807

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15235m
Alternative Names	BRPK ; PTEN-induced putative kinase protein 1
Categories	Elisa
Function	Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (By similarity). It is necessary for PARK2 recruitement to dysfunctional mitochondria to initiate their degradation.
Specificity	Natural and recombinant Mouse Serine/threonine-protein kinase PINK1, mitochondrial
Subcellular Location	Mitochondrion outer membrane Single-pass membrane protein Cytoplasm cytosol
Entryname	PINK1_MOUSE
Platform	PF00069
Protein Name	Serine/threonine-protein kinase PINK1, mitochondrial
Sequence	50: MAVRQALGRG ; LQLGRALLLR ; FAPKPGPLFG ; WGKPGPAAAW ; GRGERPGQVV ; 100: SPGAQPRPVG ; LPLPDRYRFF ; RQSVAGLAAR ; IQRQFMVRAR ; GGAGPCGRAV ; 150: FLAFGLGLGL ; IEEKQAEGRR ; AASACQEIQA ; IFTQKTKRVS ; DPLDTRCWQG ; 200: FRLEDYLIGQ ; AIGKGCNAAV ; YEATMPTLPQ ; HLEKAKHLGL ; IGKGPDVVLK ; 250: GADGEQAPGT ; PTFPFAIKMM ; WNISAGSSSE ; AILSKMSQEL ; VPASRVALAG ; 300: EYGAVTYRRS ; RDGPKQLAPH ; PNIIRVFRAF ; TSSVPLLPGA ; LADYPDMLPP ; 350: HYYPEGLGHG ; RTLFLVMKNY ; PCTLRQYLEE ; QTPSSRLATM ; MTLQLLEGVD ; 400: HLVQQGIAHR ; DLKSDNILVE ; WDSDGCPWLV ; ISDFGCCLAD ; QHVGLRLPFN ; 450: SSSVERGGNG ; SLMAPEVSTA ; HSGPSAVIDY ; SKADTWAVGA ; IAYEIFGLAN ; 500: PFYGQGSAHL ; ESRSYQEAQL ; PEMPESVPPE ; ARRLVRSLLQ ; REASKRPSAR ; 550: LAANVLHLSL ; WGEHLLALKN ; LKLDKMIAWL ; LQQSAATLLA ; DRLREKSCVE ; 580: TKLQMLFLAN ; LECEALCQAA ; LLLSSWRAAP ;
Sequence Length	580
String	Q99MQ3
Sub Unit	Interats with PARK2.

Uniprot	Q99MQ3
Gene Name	Pink1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:68943
Unigene	Mm.18539

Reference	1. "Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway." Unoki M., Nakamura Y. Oncogene20:4457-4465(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/6J. tissue: Lung. 2. "BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential." Nakajima A., Kataoka K., Hong M., Sakaguchi M., Huh N.-H. Cancer Lett.201:195-201(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY strain: ICR. tissue: Testis. 3. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: C57BL/6. strain: Czech II. tissue: Eye. tissue: Mammary gland. 5. "Ubiquitin is phosphorylated by PINK1 to activate parkin." Koyano F., Okatsu K., Kosako H., Tamura Y., Go E., Kimura M., Kimura Y., Tsuchiya H., Yoshihara H., Hirokawa T., Endo T., Fon E.A., Trempe J.F., Saeki Y., Tanaka K., Matsuda N. Nature510:162-166(2014) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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