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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Serine/threonine-protein kinase pim-3

SKU : BHE13808712

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E4599m
Categories	Elisa
Function	Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
Specificity	Natural and recombinant Mouse Serine/threonine-protein kinase pim-3
Subcellular Location	Cytoplasm
Detection Range	0.156-10ng/mL
Entryname	PIM3_MOUSE
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase pim-3
Sensitivity	0.078ng/mL
Sequence	50: MLLSKFGSLA ; HLCGPGGVDH ; LPVKILQPAK ; ADKESFEKVY ; QVGAVLGSGG ; 100: FGTVYAGSRI ; ADGLPVAVKH ; VVKERVTEWG ; SLGGVAVPLE ; VVLLRKVGAA ; 150: GGARGVIRLL ; DWFERPDGFL ; LVLERPEPAQ ; DLFDFITERG ; ALDEPLARRF ; 200: FAQVLAAVRH ; CHNCGVVHRD ; IKDENLLVDL ; RSGELKLIDF ; GSGAVLKDTV ; 250: YTDFDGTRVY ; SPPEWIRYHR ; YHGRSATVWS ; LGVLLYDMVC ; GDIPFEQDEE ; 300: ILRGRLFFRR ; RVSPECQQLI ; EWCLSLRPSE ; RPSLDQIAAH ; PWMLGTEGSV ; 326: PENCDLRLCA ; LDTDDGASTT ; SSSESL
Sequence Length	326
String	P58750
Sub Unit	Interacts with BAD (By similarity). Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM3, ubiquitination and proteasomal degradation (By similarity). Interacts with SOCS6.

Uniprot	P58750
Gene Name	Pim3
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:223775
Unigene	Mm.400129

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: FVB/N. tissue: Colon. tissue: Salivary gland. 2. "Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors." Mikkers H., Nawijn M., Allen J., Brouwers C., Verhoeven E., Jonkers J., Berns A. Mol. Cell. Biol.24:6104-6115(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION 3. "Pim3 negatively regulates glucose-stimulated insulin secretion." Vlacich G., Nawijn M.C., Webb G.C., Steiner D.F. Islets2:308-317(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DISRUPTION PHENOTYPE;INTERACTION WITH SOCS6;INDUCTION;MUTAGENESIS OF LYS-38;FUNCTION 4. "The Pim protein kinases regulate energy metabolism and cell growth." Beharry Z., Mahajan S., Zemskova M., Lin Y.W., Tholanikunnel B.G., Xia Z., Smith C.D., Kraft A.S. Proc. Natl. Acad. Sci. U.S.A.108:528-533(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808712	E4599m	96T	$776		Add to Cart

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