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ELISA Kit for Mouse Serine/threonine-protein kinase pim-2

SKU : BHE13807912

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E5627m
Alternative Names	Pim-2
Categories	Elisa
Function	Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerced by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Specificity	Natural and recombinant Mouse Serine/threonine-protein kinase pim-2
Detection Range	78-5000pg/ml
Entryname	PIM2_MOUSE
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase pim-2
Sensitivity	39.9pg/mL
Sequence	50: MARATNLNAA ; PSAGASGPPD ; SLPSTLAPPS ; PGSPAALPRA ; STPCGLSGFS ; 100: GLNIRSTSSM ; LTKPLQGHPS ; PPVTPTQPPG ; GKDRAAFEAE ; YRLGPLLGKG ; 150: GFGTVFAGHR ; VTDRRQVAIK ; VISRNRVLGW ; STVSDSVTCP ; LEVALLWKVG ; 200: EGNGHPGVIR ; LLDWFETPEG ; FMLVLERPMP ; AQDLFDYITE ; KGPLGESCSR ; 250: SFFTQVVAAV ; QHCHARGVVH ; RDIKDENILI ; DLCRGSIKLI ; DFGSGALLHD ; 300: EPYTDFDGTR ; VYSPPEWISR ; HQYHALPATV ; WSLGVLLYDM ; VCGDIPFERD ; 350: QEILEAELHF ; PAHVSPDCCA ; LIRRCLAPKP ; CSRPSLEEIL ; LDPWMQSPAE ; 370: EKPINSSKGS ; PTPLPWSLLP ;
Sequence Length	370
String	Q62070
Sub Unit	Interacts with MYC.

Uniprot	Q62070
Gene Name	Pim2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:18715
Unigene	Mm.347478

Reference	1. "Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2." van der Lugt N.M., Domen J., Verhoeven E., Linders K., van der Gulden H., Allen J., Berns A. EMBO J.14:2536-2544(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);ALTERNATIVE INITIATION 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3) strain: FVB/N. tissue: Mammary gland. 4. "Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc." Allen J.D., Verhoeven E., Domen J., van der Valk M., Berns A. Oncogene15:1133-1141(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION IN TUMORIGENESIS;INDUCTION BY IL2; IL3; IL4; IL7; IL9 AND INTERFERON-GAMMA 5. "The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor." Fox C.J., Hammerman P.S., Cinalli R.M., Master S.R., Chodosh L.A., Thompson C.B. Genes Dev.17:1841-1854(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS APOPTOTIC INHIBITOR;AUTOPHOSPHORYLATION;PHOSPHORYLATION OF BAD;ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3) 6. "The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death." Yan B., Zemskova M., Holder S., Chin V., Kraft A., Koskinen P.J., Lilly M. J. Biol. Chem.278:45358-45367(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY IL3;FUNCTION AS APOPTOTIC INHIBITOR;PHOSPHORYLATION OF BAD;MUTAGENESIS 7. "Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation." Hammerman P.S., Fox C.J., Cinalli R.M., Xu A., Wagner J.D., Lindsten T., Thompson C.B. Cancer Res.64:8341-8348(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A POSITIVE REGULATOR OF I-KAPPAB KINASE/NF-KAPPAB CASCADE;PHOSPHORYLATION OF MAP3K8/COT 8. "Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors." Mikkers H., Nawijn M., Allen J., Brouwers C., Verhoeven E., Jonkers J., Berns A. Mol. Cell. Biol.24:6104-6115(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION 9. "Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival." Hammerman P.S., Fox C.J., Birnbaum M.J., Thompson C.B. Blood105:4477-4483(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THE REGULATION OF CAP-DEPENDENT PROTEIN TRANSLATION 10. "The Pim kinases control rapamycin-resistant T cell survival and activation." Fox C.J., Hammerman P.S., Thompson C.B. J. Exp. Med.201:259-266(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;INDUCTION BY IL4 AND IL7 11. "PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate." Bohensky J., Shapiro I.M., Leshinsky S., Watanabe H., Srinivas V. J. Cell. Physiol.213:246-251(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY 12. "Pim kinase-dependent inhibition of c-Myc degradation." Zhang Y., Wang Z., Li X., Magnuson N.S. Oncogene27:4809-4819(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MYC;INTERACTION WITH MYC

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