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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Serine protease HTRA2, mitochondrial

SKU : BHE13805414

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15152m
Alternative Names	High temperature requirement protein A2 ; HtrA2 ; Omi stress-regulated endoprotease ; Serine protease 25 ; Serine proteinase OMI ; Omi ; Prss25
Categories	Elisa
Function	Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis.
Specificity	Natural and recombinant Mouse Serine protease HTRA2, mitochondrial
Subcellular Location	Mitochondrion intermembrane space Mitochondrion membrane Single-pass membrane protein Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with BID.
Entryname	HTRA2_MOUSE
Method Type	Sandwich
Platform	PF13180
Protein Name	Serine protease HTRA2, mitochondrial
Sequence	50: MAALKAGRGA ; NWSLRAWRAL ; GGIFWRKPPL ; LAPDLRALLT ; SGTPDSQIWM ; 100: TYGTPSLPAQ ; VPEGFLASRA ; DLTSRTPDLW ; ARLNVGTSGS ; SDQEARRSPG ; 150: SRRREWLAVA ; VGAGGAVVLL ; LWGWGRGLST ; VLAAVPAPPP ; TSPRSQYNFI ; 200: ADVVEKTAPA ; VVYIEILDRH ; PFSGREVPIS ; NGSGFVVASD ; GLIVTNAHVV ; 250: ADRRRVRVRL ; PSGDTYEAMV ; TAVDPVADIA ; TLRIQTKEPL ; PTLPLGRSAD ; 300: VRQGEFVVAM ; GSPFALQNTI ; TSGIVSSAQR ; PARDLGLPQN ; NVEYIQTDAA ; 350: IDFGNSGGPL ; VNLDGEVIGV ; NTMKVTAGIS ; FAIPSDRLRE ; FLHRGEKKNS ; 400: WFGTSGSQRR ; YIGVMMLTLT ; PSILIELQLR ; EPSFPDVQHG ; VLIHKVILGS ; 450: PAHRAGLRPG ; DVILAIGEKL ; AQNAEDVYEA ; VRTQSQLAVR ; IRRGSETLTL ; 458: YVTPEVTE
Sequence Length	458
String	Q9JIY5
Sub Unit	Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions (By similarity). The mature protein, but not the precursor, binds to BIRC2, BIRC3 and XIAP.

Uniprot	Q9JIY5
Gene Name	Htra2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:64704
Unigene	Mm.21880

Reference	1. "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response." Gray C.W., Ward R.V., Karran E.H., Turconi S., Rowles A., Viglienghi D., Southan C., Barton A., Fantom K.G., West A., Savopoulos J.W., Hassan N.J., Clinkenbeard H., Hanning C., Amegadzie B., Davis J.B., Dingwall C., Livi G.P., Creasy C.L.more... Eur. J. Biochem.267:5699-5710(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: BALB/c. tissue: Brain. 2. "Characterization of the mouse homolog of Omi serine protease." Faccio L., Fusco C., Zervos A.S. Submitted (1999-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/6J. tissue: Embryo. 3. "HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins." Verhagen A.M., Silke J., Ekert P.G., Pakusch M., Kaufmann H., Connolly L.M., Day C.L., Tikoo A., Burke R., Wrobel C., Moritz R.L., Simpson R.J., Vaux D.L. J. Biol. Chem.277:445-454(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;MUTAGENESIS OF ALA-134; ALA-137 AND SER-306

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805414	E15152m	96T	$776		Add to Cart

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