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ELISA Kit for Mouse Rho-associated protein kinase 1

SKU : BHE13809341

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15189m
Alternative Names	Rho-associated ; coiled-coil-containing protein kinase 1 ; Rho-associated ; coiled-coil-containing protein kinase I ; ROCK-I ; p160 ROCK-1 ; p160ROCK
Categories	Elisa
Function	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. Promotes keratinocyte terminal differentiation (By similarity). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles.
Specificity	Natural and recombinant Mouse Rho-associated protein kinase 1
Subcellular Location	Cytoplasm Cytoplasm cytoskeleton centrosome centriole Golgi apparatus membrane Peripheral membrane protein Cell projection bleb Associated with the mother centriole and an intercentriolar linker. A small proportion is associated with Golgi membranes.
Entryname	ROCK1_MOUSE
Platform	PF02185
Protein Name	Rho-associated protein kinase 1
Sequence	50: MSTGDSFETR ; FEKIDNLLRD ; PKSEVNSDCL ; LDGLDALVYD ; LDFPALRKNK ; 100: NIDNFLSRYK ; DTINKIRDLR ; MKAEDYEVVK ; VIGRGAFGEV ; QLVRHKSTRK ; 150: VYAMKLLSKF ; EMIKRSDSAF ; FWEERDIMAF ; ANSPWVVQLF ; YAFQDDRYLY ; 200: MVMEYMPGGD ; LVNLMSNYDV ; PEKWARFYTA ; EVVLALDAIH ; SMGFIHRDVK ; 250: PDNMLLDKSG ; HLKLADFGTC ; MKMNKEGMVR ; CDTAVGTPDY ; ISPEVLKSQG ; 300: GDGYYGRECD ; WWSVGVFLYE ; MLVGDTPFYA ; DSLVGTYSKI ; MNHKNSLTFP ; 350: DDNDISKEAK ; NLICAFLTDR ; EVRLGRNGVE ; EIKRHLFFKN ; DQWAWETLRD ; 400: TVAPVVPDLS ; SDIDTSNFDD ; LEEDKGDEET ; FPIPKAFVGN ; QLPFVGFTYY ; 450: SNRRYLPSAN ; ASENRSSSNV ; DKSLQESLQK ; TIYKLEEQLH ; NEMQLKDEME ; 500: QKCRTSNLKL ; DKIMKELDEE ; GNQRRNLESA ; VSQIEKEKML ; LQHRINEYQR ; 550: KVEQENEKRR ; NIENEVSTLK ; DQLEDLRKAS ; QTSQLANEKL ; TQLQKQLEEA ; 600: NDLLRTESDT ; AVRLRKSHTE ; MSKSISQLES ; LNRELQERNR ; ILENSKSQAD ; 650: KDYYQLQAVL ; EAERRDRGHD ; SEMIGDLQAR ; ITSLQEEVKH ; LKHNLERVEG ; 700: ERKEAQDMLN ; HSEKEKNNLE ; IDLNYKLKSI ; QQRLEQEVNE ; HKVTKARLTD ; 750: KHQSIEEAKS ; VAMCEMEKKL ; KEEREAREKA ; ENRVVETEKQ ; CSMLDVDLKQ ; 800: SQQKLEHLTE ; NKERMEDEVK ; NLALQLEQES ; NKRLLLQNEL ; KTQAFEADNL ; 850: KGLEKQMKQE ; INTLLEAKRL ; LEFELAQLTK ; QYRGNEGQMR ; ELQDQLEAEQ ; 900: YFSTLYKTQV ; KELKEEIEEK ; NRENLRKIQE ; LQSEKETLST ; QLDLAETKAE ; 950: SEQLARGILE ; EQYFELTQES ; KKAASRNRQE ; ITDKDHTVSR ; LEETNSVLTK ; 1000: DIEMLRKENE ; ELNERMRTAE ; EEYKLKKEEE ; INNLKAAFEK ; NISTERTLKT ; 1050: QAVNKLAEIM ; NRKDFKIDRK ; KANTQDLRKK ; EKENRKLQLE ; LNQEREKFNQ ; 1100: MVVKHQKELN ; DMQAQLVEEC ; THRNELQMQL ; ASKESDIEQL ; RAKLLDLSDS ; 1150: TSVASFPSAD ; ETDGNLPESR ; IEGWLSVPNR ; GNIKRYGWKK ; QYVVVSSKKI ; 1200: LFYNDEQDKE ; QSSPSMVLDI ; DKLFHVRPVT ; QGDVYRAETE ; EIPKIFQILY ; 1250: ANEGECRKDI ; EVEPVQQGEK ; TNFQNHKGHE ; FIPTLYHFPA ; NCEACAKPLW ; 1300: HVFKPPPALE ; CRRCHVKCHR ; DHLDKKEDLI ; SPCKVSYDVT ; SARDMLLLAC ; 1350: SQDEQKKWVT ; HLVKKIPKNP ; PSGFVRASPR ; TLSTRSTANQ ; SFRKVVKNTS ; 1354: GKTS
Sequence Length	1354
String	P70335
Sub Unit	Homodimer (By similarity). Interacts with RHOA (activated by GTP), RHOB, RHOC, GEM, MYLC2B, RHOE, PPP1R12A, LIMK1, LIMK2, TSG101, CHORDC1, DAPK3, PFN1 and JIP3 (By similarity). Interacts with FHOD1 in a Src-dependent manner (By similarity). Interacts with PTEN.

Uniprot	P70335
Gene Name	Rock1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:19877
Unigene	Mm.6710

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809341	E15189m	96T	$776		Add to Cart

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