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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Retinoic acid receptor alpha

SKU : BHE13810090

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2297m
Alternative Names	Nuclear receptor subfamily 1 group B member 1 ; Nr1b1
Categories	Elisa
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
Specificity	Natural and recombinant Mouse Retinoic acid receptor alpha
Subcellular Location	Nucleus Cytoplasm Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus is dependent on activation of PKC and the downstream MAPK phosphorylation.
Detection Range	0.312-20ng/mL
Entryname	RARA_MOUSE
Method Type	Sandwich
Platform	PF00104
Protein Name	Retinoic acid receptor alpha
Sensitivity	0.168ng/mL
Sequence	50: MASNSSSCPT ; PGGGHLNGYP ; VPPYAFFFPP ; MLGGLSPPGA ; LTSLQHQLPV ; 100: SGYSTPSPAT ; IETQSSSSEE ; IVPSPPSPPP ; LPRIYKPCFV ; CQDKSSGYHY ; 150: GVSACEGCKG ; FFRRSIQKNM ; VYTCHRDKNC ; IINKVTRNRC ; QYCRLQKCFD ; 200: VGMSKESVRN ; DRNKKKKEAP ; KPECSESYTL ; TPEVGELIEK ; VRKAHQETFP ; 250: ALCQLGKYTT ; NNSSEQRVSL ; DIDLWDKFSE ; LSTKCIIKTV ; EFAKQLPGFT ; 300: TLTIADQITL ; LKAACLDILI ; LRICTRYTPE ; QDTMTFSDGL ; TLNRTQMHNA ; 350: GFGPLTDLVF ; AFANQLLPLE ; MDDAETGLLS ; AICLICGDRQ ; DLEQPDKVDM ; 400: LQEPLLEALK ; VYVRKRRPSR ; PHMFPKMLMK ; ITDLRSISAK ; GAERVITLKM ; 450: EIPGSMPPLI ; QEMLENSEGL ; DTLSGQSGGG ; TRDGGGLAPP ; PGSCSPSLSP ; 462: SSHRSSPATQ ; SP
Sequence Length	462
String	P11416
Sub Unit	Interacts with PRMT2 (By similarity). Interacts with LRIF1 (By similarity). Interacts with NCOA7 in a ligand-inducible manner. Interacts with MLL5. Interacts (via the ligand-binding domain) with PRAME; interaction is direct and ligand (retinoic acid)-dependent. Interacts with PRKAR1A; the interaction negatively. regulates RARA transcriptional activity. Interacts with NCOR1 and NCOR2; the interaction occurs in the absence of ligand and represses transciptional activity. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with CDK7; the interaction is enhanced by interaction with GTF2H3. Interacts with GTF2H3; the interaction requires prior phosphorylation on Ser-369 which then enhances interaction with CDK7.

Uniprot	P11416
Gene Name	Rara
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:19401
Unigene	Mm.439744

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810090	E2297m	96T	$776		Add to Cart

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