Proto-oncogene Neu ; Proto-oncogene c-ErbB-2 ; p185erbB2 ; CD340 ; Kiaa3023 ; Neu
Categories
Elisa
Function
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Specificity
Natural and recombinant Mouse Receptor tyrosine-protein kinase erbB-2
Subcellular Location
Cell membrane Single-pass type I membrane protein Cytoplasm perinuclear region Nucleus
Homodimer. Heterodimer with ERBB3. Heterodimer with each of the other ERBB receptors (Potential). Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1197. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1249) with MEMO1. Interacts with MUC1. Interacts (when phosphorylated on Tyr-1140) with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-1249) with ERBB2IP. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, RPA94 and ACTB.