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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 2

SKU : BHE13810287

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1786m
Alternative Names	Tyrosine-protein kinase RIPK2 ; 2.7.10.2
Categories	Elisa
Function	Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is release from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Specificity	Natural and recombinant Mouse Receptor-interacting serine/threonine-protein kinase 2
Subcellular Location	Cytoplasm
Detection Range	0.156-10ng/mL
Entryname	RIPK2_MOUSE
Method Type	Sandwich
Platform	PF00619
Protein Name	Receptor-interacting serine/threonine-protein kinase 2
Sensitivity	0.082ng/mL
Sequence	50: MNGDAICSAL ; PPIPYHKLAD ; LHYLSRGASG ; TVSSARHADW ; RVRVAVKHLH ; 100: IHTPLLDSER ; NDILREAEIL ; HKARFSYILP ; ILGICNEPEF ; LGIVTEYMPN ; 150: GSLNELLHRK ; TEYPDIAWPL ; RFRILHEIAL ; GVNYLHNMNP ; PLLHHDLKTQ ; 200: NILLDNEFHV ; KIADFGLSKW ; RMMSLSQSRS ; YKSAPEGGTI ; IYMPPENYEP ; 250: GQKSRASVKH ; DIYSYAVIMW ; EVLSRKQPFE ; EVTNPLQIMY ; SVSQGHRPDT ; 300: SEENLPFDIP ; HRGLMISLIQ ; SGWAQNPDER ; PSFLKCLIEL ; EPVLRTFEDI ; 350: TFLEAVIQLK ; KAKIQSSSST ; IHLCDKKMDL ; SLNIPANHPP ; QEESCGSSLL ; 400: SRNTGSPGPS ; RSLSAPQDKG ; FLSGAPQDCS ; SLKAHHCPGN ; HSWDGIVSVP ; 450: PGAAFCDRRA ; SSCSLAVISP ; FLVEKGSERP ; PIGIAQQWIQ ; SKREAIVSQM ; 500: TEACLNQSLD ; ALLSRDLIMK ; EDYELISTKP ; TRTSKVRQLL ; DTSDIQGEEF ; 539: AKVVVQKLKD ; NKQLGLQPYP ; EVPVLSKAPP ; SNFPQNKSL
Sequence Length	539
String	P58801
Sub Unit	Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex. Interacts with NOD1 and NOD2. Interacts with MAP3K4; this interaction sequesters RIPK2 from the NOD2 signaling pathway. Interacts with IKBKG/NEMO. The polyubiquitinated protein interacts with MAP3K7/TAK1.

Uniprot	P58801
Gene Name	Ripk2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:192656
Unigene	Mm.112765

Reference	1. "Involvement of receptor-interacting protein 2 in innate and adaptive immune responses." Chin A.I., Dempsey P.W., Bruhn K., Miller J.F., Xu Y., Cheng G. Nature416:190-194(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/6. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: 129. tissue: Mammary gland. 3. "RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs." Park J.H., Kim Y.G., McDonald C., Kanneganti T.D., Hasegawa M., Body-Malapel M., Inohara N., Nunez G. J. Immunol.178:2380-2386(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 4. "The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens." Hsu Y.M., Zhang Y., You Y., Wang D., Li H., Duramad O., Qin X.F., Dong C., Lin X. Nat. Immunol.8:198-205(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CARD9 5. "Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands." Magalhaes J.G., Lee J., Geddes K., Rubino S., Philpott D.J., Girardin S.E. Eur. J. Immunol.41:1445-1455(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE

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