Protein kinase Akt-2 ; Protein kinase B beta ; PKB beta ; RAC-PK-beta
Categories
Elisa
Function
One of the few specific substrates of AKT2 identified so far is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. AKT2 is also specifically involved in skeletal muscle differentiation. Phosphorylates CLK2 on 'Thr-343'.
Specificity
Natural and recombinant Mouse RAC-beta serine/threonine-protein kinase
Subcellular Location
Cytoplasm Nucleus Cell membrane Peripheral membrane protein Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts (By similarity). By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containg increased PI(3,4,5)P3 or PI(3,4)P2.