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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse RAC-alpha serine/threonine-protein kinase

SKU : BHE13800926

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0382m
Alternative Names	AKT1 kinase ; Protein kinase B ; PKB ; Protein kinase B alpha ; PKB alpha ; Proto-oncogene c-Akt ; RAC-PK-alpha ; Thymoma viral proto-oncogene ; Akt ; Rac
Categories	Elisa
Function	AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
Specificity	Natural and recombinant Mouse RAC-alpha serine/threonine-protein kinase
Subcellular Location	Cytoplasm Nucleus Cell membrane Nucleus after activation by integrin-linked protein kinase 1 (ILK1) (By similarity). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus.
Detection Range	0.312-20ng/mL
Entryname	AKT1_MOUSE
Method Type	Sandwich
Platform	PF00169
Protein Name	RAC-alpha serine/threonine-protein kinase
Sensitivity	0.173ng/mL
Sequence	50: MNDVAIVKEG ; WLHKRGEYIK ; TWRPRYFLLK ; NDGTFIGYKE ; RPQDVDQRES ; 100: PLNNFSVAQC ; QLMKTERPRP ; NTFIIRCLQW ; TTVIERTFHV ; ETPEEREEWA ; 150: TAIQTVADGL ; KRQEEETMDF ; RSGSPSDNSG ; AEEMEVSLAK ; PKHRVTMNEF ; 200: EYLKLLGKGT ; FGKVILVKEK ; ATGRYYAMKI ; LKKEVIVAKD ; EVAHTLTENR ; 250: VLQNSRHPFL ; TALKYSFQTH ; DRLCFVMEYA ; NGGELFFHLS ; RERVFSEDRA ; 300: RFYGAEIVSA ; LDYLHSEKNV ; VYRDLKLENL ; MLDKDGHIKI ; TDFGLCKEGI ; 350: KDGATMKTFC ; GTPEYLAPEV ; LEDNDYGRAV ; DWWGLGVVMY ; EMMCGRLPFY ; 400: NQDHEKLFEL ; ILMEEIRFPR ; TLGPEAKSLL ; SGLLKKDPTQ ; RLGGGSEDAK ; 450: EIMQHRFFAN ; IVWQDVYEKK ; LSPPFKPQVT ; SETDTRYFDE ; EFTAQMITIT ; 480: PPDQDDSMEC ; VDSERRPHFP ; QFSYSASGTA ;
Sequence Length	480
String	P31750
Sub Unit	Interacts with AGAP2 isoform 2 (PIKE-A) in the presence of guanine nucleotides. The C-terminus interacts with CCDC88A/GRDN and THEM4. Interacts with AKTIP (By similarity). Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting 14-3-3 binding and cell-cycle progression. Interacts with MAP3K5 and TRAF6 (By similarity). Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE/14-3-3-binding. Interacts with TNK2. Interacts with CLK2 and PPP2R5B. Interacts with STK3/MST2 and STK4/MST1.

Uniprot	P31750
Gene Name	Akt1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:11651
Unigene	Mm.6645

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800926	E0382m	96T	$776		Add to Cart

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