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ELISA Kit for Mouse Proto-oncogene c-Fos

SKU : BHE13805029

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1291m
Alternative Names	Cellular oncogene fos
Categories	Elisa
Function	Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
Specificity	Natural and recombinant Mouse Proto-oncogene c-Fos
Subcellular Location	Nucleus
Detection Range	0.312-20ng/mL
Entryname	FOS_MOUSE
Method Type	Sandwich
Platform	PF00170
Protein Name	Proto-oncogene c-Fos
Sensitivity	0.181ng/mL
Sequence	50: MMFSGFNADY ; EASSSRCSSA ; SPAGDSLSYY ; HSPADSFSSM ; GSPVNTQDFC ; 100: ADLSVSSANF ; IPTVTAISTS ; PDLQWLVQPT ; LVSSVAPSQT ; RAPHPYGLPT ; 150: QSAGAYARAG ; MVKTVSGGRA ; QSIGRRGKVE ; QLSPEEEEKR ; RIRRERNKMA ; 200: AAKCRNRRRE ; LTDTLQAETD ; QLEDEKSALQ ; TEIANLLKEK ; EKLEFILAAH ; 250: RPACKIPDDL ; GFPEEMSVAS ; LDLTGGLPEA ; STPESEEAFT ; LPLLNDPEPK ; 300: PSLEPVKSIS ; NVELKAEPFD ; DFLFPASSRP ; SGSETSRSVP ; DVDLSGSFYA ; 350: ADWEPLHSNS ; LGMGPMVTEL ; EPLCTPVVTC ; TPGCTTYTSS ; FVFTYPEADS ; 380: FPSCAAAHRK ; GSSSNEPSSD ; SLSSPTLLAL ;
Sequence Length	380
String	P01101
Sub Unit	Heterodimer; with JUN (By similarity). Interacts with MAFB. Component of the SMAD3/SMAD4/JUN/FOS complex required for syngernistic TGF-beta-mediated transcription at the AP1 promoter site. Interacts with SMAD3; the interaction is weak even on TGF-beta activation. Interacts with MAFB (By similarity). Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.

Uniprot	P01101
Gene Name	Fos
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:14281
Unigene	Mm.246513

Reference	1. "Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini." van Beveren C., van Straaten F., Curran T., Mueller R., Verma I.M. Cell32:1241-1255(1983) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 2. "Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene." Meijlink F., Curran T., Miller A.D., Verma I.M. Proc. Natl. Acad. Sci. U.S.A.82:4987-4991(1985) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: FVB/N. tissue: Mammary gland. 4. "Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ." Mittelstadt P.R., Ashwell J.D. J. Biol. Chem.276:29603-29610(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DSIPI 5. "Molecular interpretation of ERK signal duration by immediate early gene products." Murphy L.O., Smith S., Chen R.H., Fingar D.C., Blenis J. Nat. Cell Biol.4:556-564(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-325; THR-331; SER-362 AND SER-374;FUNCTION;MUTAGENESIS OF THR-325; THR-331; PHE-343; TYR-345; SER-362 AND SER-374 6. "Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor." Monje P., Marinissen M.J., Gutkind J.S. Mol. Cell. Biol.23:7030-7043(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-232; THR-325; THR-331; SER-362 AND SER-374;FUNCTION;MUTAGENESIS OF THR-232; THR-325; THR-331 AND SER-374 7. "Essential role of RSK2 in c-Fos-dependent osteosarcoma development." David J.-P., Mehic D., Bakiri L., Schilling A.F., Mandic V., Priemel M., Idarraga M.H., Reschke M.O., Hoffmann O., Amling M., Wagner E.F. J. Clin. Invest.115:664-672(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-362;FUNCTION 8. "c-Fos activates and physically interacts with specific enzymes of the pathway of synthesis of polyphosphoinositides." Alfonso Pecchio A.R., Cardozo Gizzi A.M., Renner M.L., Molina-Calavita M., Caputto B.L. Mol. Biol. Cell22:4716-4725(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 9. "The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity." Ferrero G.O., Velazquez F.N., Caputto B.L. Oncogene31:3381-3391(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CDS1 AND PI4K2A;TYROSINE PHOSPHORYLATION BY SRC;MUTAGENESIS OF LYS-139; ARG-144 AND ARG-146

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