JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Protein SET

SKU : BHE13811047

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E14249m
Alternative Names	Phosphatase 2A inhibitor I2PP2A ; I-2PP2A ; Template-activating factor I ; TAF-I
Categories	Elisa
Function	Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
Specificity	Natural and recombinant Mouse Protein SET
Subcellular Location	Cytoplasm cytosol Endoplasmic reticulum Nucleus nucleoplasm In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. Following CTL attack, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium. The SET complex is associated with the endoplasmic reticulum.
Detection Range	0.156-10ng/mL
Entryname	SET_MOUSE
Method Type	Sandwich
Platform	PF00956
Protein Name	Protein SET
Sensitivity	0.078ng/mL
Sequence	50: MAPKRQSAIL ; PQPKKPRPAA ; APKLEDKSAS ; PGLPKGEKEQ ; QEAIEHIDEV ; 100: QNEIDRLNEQ ; ASEEILKVEQ ; KYNKLRQPFF ; QKRSELIAKI ; PNFWVTTFVN ; 150: HPQVSALLGE ; EDEEALHYLT ; RVEVTEFEDI ; KSGYRIDFYF ; DENPYFENKV ; 200: LSKEFHLNES ; GDPSSKSTEI ; KWKSGKDLTK ; RSSQTQNKAS ; RKRQHEEPES ; 250: FFTWFTDHSD ; AGADELGEVI ; KDDIWPNPLQ ; YYLVPDMDDE ; EGEAEDDDDD ; 289: DEEEEGLEDI ; DEEGDEDEGE ; EDDDEDEGEE ; GEEDEGEDD
Sequence Length	289
String	Q9EQU5
Sub Unit	Isoform 1 and isoform 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. Isoform 1 and isoform 2 interact also with histones. Isoform 2 is a component of the SET complex, which also contains ANP32A, APEX1, HMGB2 and NME1, but not NME2. Within this complex, directly interacts with NME1 and with HMGB2. Interacts with SETBP1 (By similarity). Interacts with SGOL1 (By similarity). Interacts with APBB1.

Uniprot	Q9EQU5
Gene Name	Set
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:56086
Unigene	Mm.335942

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13811047	E14249m	96T	$776		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.