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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Protein KIBRA

SKU : BHE13806093

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2983m
Alternative Names	Kidney and brain protein ; KIBRA ; WW domain-containing protein 1 ; Kiaa0869
Categories	Elisa
Function	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance (By similarity). Regulates collagen-stimulated activation of the ERK/MAPK cascade.
Specificity	Natural and recombinant Mouse Protein KIBRA
Subcellular Location	Cytoplasm Cytoplasm perinuclear region Nucleus Cell projection ruffle membrane Co-localizes with PRKCZ in the perinuclear region.
Entryname	KIBRA_MOUSE
Platform	PF00397
Protein Name	Protein KIBRA
Sequence	50: MPRPELPLPE ; GWEEARDFDG ; KVYYIDHRNR ; TTSWIDPRDR ; YTKPLTFADC ; 100: ISDELPLGWE ; EAYDPQVGDY ; FIDHNTKTTQ ; IEDPRVQWRR ; EQEHMLKDYL ; 150: VVAQEALSAQ ; KEIYQVKQQR ; LELAQQEYQQ ; LHAVWEHKLG ; SQVSLVSGSS ; 200: SSSKYDPEIL ; KAEIATAKSR ; VNKLKREMVH ; LQHELQFKER ; GFQTLKKIDE ; 250: RMSDAQGGYK ; LDEAQAVLRE ; TKAIKKAITC ; GEKEKQDLIK ; SLAMLKDGFR ; 300: TDRGSHSDLW ; SSSSSLESSS ; FPMPKQFLDV ; SSQTDISGSF ; STSSNNQLAE ; 350: KVRLRLRYEE ; AKRRIANLKI ; QLAKLDSEAW ; PGVLDSERDR ; LILINEKEEL ; 400: LKEMRFISPR ; KWTQGEVEQL ; EMARRRLEKD ; LQAARDTQSK ; ALTERLKLNS ; 450: KRNQLVRELE ; EATRQVATLH ; SQLKSLSSSM ; QSLSSGSSPG ; SLTSSRGSLA ; 500: ASSLDSSTSA ; SFTDLYYDPF ; EQLDSELQSK ; VELLFLEGAT ; GFRPSGCITT ; 550: IHEDEVAKTQ ; KAEGGSRLQA ; LRSLSGTPRS ; MTSLSPRSSL ; SSPSPPCSPL ; 600: ITDPLLTGDA ; FLAPLEFEDT ; ELSTTLCELN ; LGGSGTQERY ; RLEEPGPEGK ; 650: PLGQAASVAP ; GCGLKVACVS ; AAVSDESVAG ; DSGVYEASAQ ; RPGTSEAAAF ; 700: DSDESEAVGA ; TRVQIALKYD ; EKNKQFAILI ; IQLSHLSALS ; LQQDQKVNIR ; 750: VAILPCSESS ; TCLFRTRPLD ; SANTLVFNEA ; FWVSISYPAL ; HQKTLRVDVC ; 800: TTDRSHTEEC ; LGGAQISLAE ; VCRSGERSTR ; WYNLLSYKYL ; KKQCREPQPT ; 850: EAPGPDHVDA ; VSALLEQTAV ; ELEKRQEGRS ; SSQTLEGSWT ; YEEEASENEA ; 900: VAEEEEEGEE ; DVFTEKVSPE ; AEECPALKVD ; RETNTDSVAP ; SPTVVRPKDR ; 950: RVGAPSTGPF ; LRGNTIIRSK ; TFSPGPQSQY ; VCRLNRSDSD ; SSTLSKKPPF ; 1000: VRNSLERRSV ; RMKRPSSVKS ; LRTERLIRTS ; LDLELDLQAT ; RTWHSQLTQE ; 1050: ISVLKELKEH ; LEQAKNHGEK ; ELPQWLREDE ; RFRLLLRMLE ; KKVDRGEHKS ; 1100: ELQADKMMRA ; AAKDVHRLRG ; QSCKEPPEVQ ; SFREKMAFFT ; RPRMNIPALS ; 1104: ADDV
Sequence Length	1104
String	Q5SXA9
Sub Unit	Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4.

Uniprot	Q5SXA9
Gene Name	Wwc1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:211652
Unigene	Mm.31267

Reference	1. "Protein-coding sequence of KIBRA from Mus musculus." Kremerskothen J. Submitted (2005-10) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: 129/SvEv. 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Seino S., Nishimura M., Nagase T., Ohara O., Koga H. Submitted (2005-02) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-1104 tissue: Pancreatic islet. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 146-1104 strain: FVB/N. tissue: Mammary gland. tissue: Mammary tumor. tissue: Salivary gland. 5. "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-887 AND SER-891;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Liver. 6. "KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling." Hilton H.N., Stanford P.M., Harris J., Oakes S.R., Kaplan W., Daly R.J., Ormandy C.J. Biochim. Biophys. Acta1783:383-393(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE

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