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ELISA Kit for Mouse Protein fantom

SKU : BHE13804643

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3274m
Alternative Names	Nephrocystin-8 ; RPGR-interacting protein 1-like protein ; RPGRIP1-like protein ; Ftm ; Nphp8
Categories	Elisa
Function	Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (By similarity). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions in kidney cells together with NPHP1 and NPHP4. Does not seem to be strictly required for ciliogenesis.
Specificity	Natural and recombinant Mouse Protein fantom
Subcellular Location	Cytoplasm Cytoplasm cytoskeleton cilium basal body Cytoplasm cytoskeleton cilium axoneme Cytoplasm cytoskeleton centrosome Cell junction tight junction In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions.
Entryname	FTM_MOUSE
Platform	PF00168
Protein Name	Protein fantom
Sequence	50: MSGPSDETAG ; DLPVKDTGLN ; LFGVGGLQET ; STARTVKTRQ ; AVSRVSREEL ; 100: EDRFLRLHDE ; NILLKQHARK ; QEDKIKRMAT ; KLIRLVNDKK ; RYERVGGGPK ; 150: RLGRDVEMEE ; MIEQLQEKVH ; ELERQNEVLK ; NRLISAKQQL ; QVQGHRQTSY ; 200: SRVQARVNTG ; RRRASASAGS ; QECPGKGLRF ; QNVDEAETVQ ; PTLTKYSNSL ; 250: LEEARGEIRN ; LENVIQSQRG ; QIEELEHLAE ; ILKTQLKRKE ; NEIELSLLQL ; 300: REQQATDQRS ; NIRDNVETIK ; LHKQLVEKSN ; ALSVIEGKFI ; QLQEKQRTLR ; 350: ISHDALMANG ; DELNKQLKEQ ; RLKCCSLEKQ ; LHSVRFSERR ; VEELQDRIND ; 400: LEKERELLKE ; NYDKLYNSAF ; SAAHEEQWKL ; KEQQMKVQIA ; QLETALKSDL ; 450: TDKTEVLDKL ; KTERDQNEKL ; VQENRDLQLQ ; CLQQKQRLHE ; LQSRLKFFNQ ; 500: ESDINADDLS ; EALLLIKAQK ; EQKNGDLSFL ; EKVDSKINKD ; LDRSMKELQA ; 550: THAETVQELE ; KTRNMLIMQH ; KINKDYQMEV ; ETVTQKMENL ; QQDYELKVEQ ; 600: YVHLLDIRAA ; RIQKLEAQLK ; DIAYGTKQYK ; FKPEIMPDDS ; VDEFDETIHL ; 650: ERGENLFEIH ; INKVTFSSEV ; LRASGDKELV ; TFCTYAFYDF ; ELQTTPIVRG ; 700: LYPEYNFTSQ ; YLVHVNDLFL ; QYIQKNTVTL ; ELHQAHSTDY ; ETIAACQLRF ; 750: HEILEKSGRI ; FCTTSLVGTK ; GDIPNFGTVE ; YWFRLRVPMD ; QAIRLYRERA ; 800: KALGYITSSF ; KKPEKMQLSS ; QQAATTAQIS ; PAESTDGNLN ; ELHVTVRCCT ; 850: GLQSRASYLQ ; PHAYVVYKFF ; DFPDHDTAIV ; PSSNDPQFDD ; HMCFPVPMNM ; 900: DLDRYLKSES ; LSFYVFDDSD ; TQENIYMGKV ; NVPLISLAHD ; KCISGIFELM ; 950: DKEKHAAGTI ; QVILKWKFTY ; LPPSGSITTE ; DLGKFVCREE ; PEAVQRLPPK ; 1000: SSDVTSVVAP ; KPKPRQRLTF ; VDKKVSFADT ; ISHPSPETSP ; PPKDIKDSSP ; 1050: EVGPKPENGL ; SAVAYPSKXS ; GVAKVEENVG ; EMQQGKEDDI ; SFLSEGQLAS ; 1100: GSVASSEDET ; EITEELEPED ; EDRSASDSDD ; CIIPSSVSTN ; TKQPSEEIRI ; 1150: EIIALNLNDS ; QITREDTIQR ; LFIECRFYSL ; PAEETPMSLP ; KPQSGQWVYY ; 1200: NYSNVIYLDK ; ENNPAVRDIL ; KAILQRRELP ; HRSVRFTVVS ; DPPEDEQDLE ; 1250: CEDIGVAHVD ; LADLFQKGRD ; IIEQDIDVLD ; ARTDGGTIGK ; LKVTVEALHA ; 1264: LRSVYEQNRK ; DLEA
Sequence Length	1264
String	Q8CG73
Sub Unit	Interacts with NPHP4 in a complex containing NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Interacts with TBXA2R (via C-terminus) (By similarity). Interacts with IQCB1; the interaction likely requires additional interactors.

Uniprot	Q8CG73
Gene Name	Rpgrip1l
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:244585
Unigene	Mm.324592

Reference	1. "The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster." Peters T., Ausmeier K., Dildrop R., Ruether U. Mamm. Genome13:186-188(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION strain: Swiss Webster / NIH. 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (2005-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 4. "Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation." Peters T., Ausmeier K., Ruether U. Mamm. Genome10:983-986(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE 5. "Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways." Sang L., Miller J.J., Corbit K.C., Giles R.H., Brauer M.J., Otto E.A., Baye L.M., Wen X., Scales S.J., Kwong M., Huntzicker E.G., Sfakianos M.K., Sandoval W., Bazan J.F., Kulkarni P., Garcia-Gonzalo F.R., Seol A.D., O'Toole J.F., Held S., Reutter H.M., Lane W.S., Rafiq M.A., Noor A., Ansar M., Devi A.R., Sheffield V.C., Slusarski D.C., Vincent J.B., Doherty D.A., Hildebrandt F., Reiter J.F., Jackson P.K.more... Cell145:513-528(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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