ELISA Kit for Mouse Protein atonal homolog 1

Mfr.No.	E0255m
Alternative Names	Helix-loop-helix protein mATH-1 ; mATH1 ; Ath1
Categories	Elisa
Function	Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
Specificity	Natural and recombinant Mouse Protein atonal homolog 1
Subcellular Location	Nucleus
Detection Range	0.78-50ng/mL
Entryname	ATOH1_MOUSE
Method Type	Sandwich
Platform	PF00010
Protein Name	Protein atonal homolog 1
Sensitivity	0.409ng/mL
Sequence	50: MSRLLHAEEW ; AEVKELGDHH ; RHPQPHHVPP ; LTPQPPATLQ ; ARDLPVYPAE ; 100: LSLLDSTDPR ; AWLTPTLQGL ; CTARAAQYLL ; HSPELGASEA ; AAPRDEADSQ ; 150: GELVRRSGCG ; GLSKSPGPVK ; VREQLCKLKG ; GVVVDELGCS ; RQRAPSSKQV ; 200: NGVQKQRRLA ; ANARERRRMH ; GLNHAFDQLR ; NVIPSFNNDK ; KLSKYETLQM ; 250: AQIYINALSE ; LLQTPNVGEQ ; PPPPTASCKN ; DHHHLRTASS ; YEGGAGASAV ; 300: AGAQPAPGGG ; PRPTPPGPCR ; TRFSGPASSG ; GYSVQLDALH ; FPAFEDRALT ; 350: AMMAQKDLSP ; SLPGGILQPV ; QEDNSKTSPR ; SHRSDGEFSP ; HSHYSDSDEA ; 351: S
Sequence Length	351
String	P48985
Sub Unit	Efficient DNA binding requires dimerization with another bHLH protein.

Reference	1. "A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system." Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R. J. Biol. Chem.270:8730-8738(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] strain: 129/J. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: FVB/N. tissue: Colon. 3. "Generation of neurons by transient expression of neural bHLH proteins in mammalian cells." Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J., Turner D.L. Development127:693-702(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION

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BHE13801849	E0255m	96T	$776		Add to Cart