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ELISA Kit for Mouse Presenilin-1

SKU : BHE13809900

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15382m
Alternative Names	Protein S182 ; Ad3h ; Psnl1
Categories	Elisa
Function	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Specificity	Natural and recombinant Mouse Presenilin-1
Subcellular Location	Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Cell surface
Entryname	PSN1_MOUSE
Platform	PF01080
Protein Name	Presenilin-1
Sequence	50: MTEIPAPLSY ; FQNAQMSEDS ; HSSSAIRSQN ; DSQERQQQHD ; RQRLDNPEPI ; 100: SNGRPQSNSR ; QVVEQDEEED ; EELTLKYGAK ; HVIMLFVPVT ; LCMVVVVATI ; 150: KSVSFYTRKD ; GQLIYTPFTE ; DTETVGQRAL ; HSILNAAIMI ; SVIVIMTILL ; 200: VVLYKYRCYK ; VIHAWLIISS ; LLLLFFFSFI ; YLGEVFKTYN ; VAVDYVTVAL ; 250: LIWNFGVVGM ; IAIHWKGPLR ; LQQAYLIMIS ; ALMALVFIKY ; LPEWTAWLIL ; 300: AVISVYDLVA ; VLCPKGPLRM ; LVETAQERNE ; TLFPALIYSS ; TMVWLVNMAE ; 350: GDPEAQRRVP ; KNPKYNTQRA ; ERETQDSGSG ; NDDGGFSEEW ; EAQRDSHLGP ; 400: HRSTPESRAA ; VQELSGSILT ; SEDPEERGVK ; LGLGDFIFYS ; VLVGKASATA ; 450: SGDWNTTIAC ; FVAILIGLCL ; TLLLLAIFKK ; ALPALPISIT ; FGLVFYFATD ; 467: YLVQPFMDQL ; AFHQFYI
Sequence Length	467
String	P49769
Sub Unit	Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity. Other components which are associated with the complex include SLC25A64, SLC5A7, PHB and PSEN1 isoform 3. Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment. Associates with proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Associates with NOTCH1. Associates with cadherin/catenin adhesion complexes through direct binding to CDH1 or CDH2. Interaction with CDH1 stabilizes the complex and stimulates cell-cell aggregation. Interaction with CDH2 is essential for trafficking of CDH2 from the endoplasmic reticulum to the plasma membrane. Interacts with CTNND2, CTNNB1, HERPUD1, FLNA, FLNB, MTCH1, PKP4 and PARL. Interacts through its N-terminus with isoform 3 of GFAP. Interacts with DOCK3.

Uniprot	P49769
Gene Name	Psen1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:19164
Unigene	Mm.998

Reference	1. "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.-F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R.J., Wasco W., da Silva H.A.R., Haines J.L., Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M., St George-Hyslop P.H.more... Nature375:754-760(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) tissue: Brain. 2. "Transcriptional regulation of the mouse presenilin-1 gene." Mitsuda N., Roses A.D., Vitek M.P. J. Biol. Chem.272:23489-23497(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1) strain: 129/SvJ. 3. "Molecular cloning and tissue distribution of presenilin-1 in senenscence accelerated mice (SAM P8) mice." Kumar V.B., Vyas K.C., Choudhary V., Franko M., Flood J.F., Morley J.E. Submitted (1999-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) strain: SAM P8. tissue: Hippocampus. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2) strain: FVB/N. tissue: Eye. tissue: Liver. tissue: Mammary gland. tissue: Retina. 5. "Isolation and characterization of novel presenilin binding protein." Kashiwa A., Yoshida H., Lee S., Paladino T., Liu Y., Chen Q., Dargusch R., Schubert D., Kimura H. J. Neurochem.75:109-116(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DOCK3 tissue: Brain. 6. "Phosphoproteomic analysis of the developing mouse brain." Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P. Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Embryonic brain. 7. "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367; THR-370 AND SER-371;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Liver. 8. "The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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