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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Prelamin-A/C

SKU : BHE13806195

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11923m
Alternative Names	Lmn1
Categories	Elisa
Function	Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Specificity	Natural and recombinant Mouse Prelamin-A/C
Subcellular Location	Nucleus Nucleus envelope Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.
Detection Range	0.156-10ng/mL
Entryname	LMNA_MOUSE
Method Type	Sandwich
Platform	PF00038
Protein Name	Prelamin-A/C
Sensitivity	0.078ng/mL
Sequence	50: METPSQRRAT ; RSGAQASSTP ; LSPTRITRLQ ; EKEDLQELND ; RLAVYIDRVR ; 100: SLETENAGLR ; LRITESEEVV ; SREVSGIKAA ; YEAELGDARK ; TLDSVAKERA ; 150: RLQLELSKVR ; EEFKELKARN ; TKKEGDLLAA ; QARLKDLEAL ; LNSKEAALST ; 200: ALSEKRTLEG ; ELHDLRGQVA ; KLEAALGEAK ; KQLQDEMLRR ; VDAENRLQTL ; 250: KEELDFQKNI ; YSEELRETKR ; RHETRLVEID ; NGKQREFESR ; LADALQELRA ; 300: QHEDQVEQYK ; KELEKTYSAK ; LDNARQSAER ; NSNLVGAAHE ; ELQQSRIRID ; 350: SLSAQLSQLQ ; KQLAAKEAKL ; RDLEDSLARE ; RDTSRRLLAE ; KEREMAEMRA ; 400: RMQQQLDEYQ ; ELLDIKLALD ; MEIHAYRKLL ; EGEEERLRLS ; PSPTSQRSRG ; 450: RASSHSSQSQ ; GGGSVTKKRK ; LESSESRSSF ; SQHARTSGRV ; AVEEVDEEGK ; 500: FVRLRNKSNE ; DQSMGNWQIR ; RQNGDDPLMT ; YRFPPKFTLK ; AGQVVTIWAS ; 550: GAGATHSPPT ; DLVWKAQNTW ; GCGSSLRTAL ; INSTGEEVAM ; RKLVRSLTMV ; 600: EDNEDDDEDG ; EELLHHHRGS ; HCSGSGDPAE ; YNLRSRTVLC ; GTCGQPADKA ; 650: AGGAGAQVGG ; SISSGSSASS ; VTVTRSFRSV ; GGSGGGSFGD ; NLVTRSYLLG ; 665: NSSPRSQSSQ ; NCSIM
Sequence Length	665
String	P48678
Sub Unit	Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1 and with emerin. Proteolytically processed isoform A interacts with NARF (By similarity). Interacts with SREBF1, SREBF2, SUN1, SUN2 and TMEM43. Prelamin-A/C interacts with EMD (By similarity). Interacts with MLIP; may regulate MLIP localization to the nucleus envelope.

Uniprot	P48678
Gene Name	Lmna
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16905
Unigene	Mm.243014

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806195	E11923m	96T	$776		Add to Cart

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