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ELISA Kit for Mouse Poly [ADP-ribose] polymerase 1

SKU : BHE13808040

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0947m
Alternative Names	ADP-ribosyltransferase diphtheria toxin-like 1 ; ARTD1 ; NAD(+) ADP-ribosyltransferase 1 ; ADPRT 1 ; Poly[ADP-ribose] synthase 1 ; msPARP ; Adprp ; Adprt ; Adprt1
Categories	Elisa
Function	Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity). Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR.
Specificity	Natural and recombinant Mouse Poly [ADP-ribose] polymerase 1
Subcellular Location	Nucleus
Detection Range	78-5000pg/mL
Entryname	PARP1_MOUSE
Method Type	Sandwich
Platform	PF00533
Protein Name	Poly [ADP-ribose] polymerase 1
Sensitivity	39pg/mL
Sequence	50: MAEASERLYR ; VQYAKSGRAS ; CKKCSESIPK ; DSLRMAIMVQ ; SPMFDGKVPH ; 100: WYHFSCFWKV ; GQSIRHPDVE ; VDGFSELRWD ; DQQKVKKTAE ; AGGVAGKGQD ; 150: GSGGKAEKTL ; GDFAAEYAKS ; NRSMCKGCLE ; KIEKGQMRLS ; KKMVDPEKPQ ; 200: LGMIDRWYHP ; TCFVKKRDEL ; GFRPEYSASQ ; LKGFSLLSAE ; DKEALKKQLP ; 250: AIKNEGKRKG ; DEVDGTDEVA ; KKKSRKETDK ; YSKLEKALKA ; QNELIWNIKD ; 300: ELKKACSTND ; LKELLIFNQQ ; QVPSGESAIL ; DRVADGMAFG ; ALLPCKECSG ; 350: QLVFKSDAYY ; CTGDVTAWTK ; CMVKTQNPSR ; KEWVTPKEFR ; EISYLKKLKV ; 400: KKQDRIFPPE ; SSAPITVHWP ; LSVTSAPTAV ; NSSAPADKPL ; SNMKILTLGK ; 450: LSQNKDEAKA ; VIEKLGGKLT ; GSANKASLCI ; SIKKEVEKMN ; KKMEEVKEAN ; 500: IRVVSEDFLQ ; DVSASTKSLQ ; DLLSAHSLSP ; WGAEVKAEPG ; EVVAPRGKSA ; 550: APSKKSKGCF ; KEEGVNKSEK ; RMKLTLKGGA ; AVDPDSGLEH ; SAHVLEKGGK ; 600: VFSATLGLVD ; IVKGTNSYYK ; LQLLEDDKES ; RYWIFRSWGR ; LGTVIGSNKL ; 650: EQMPSKEEAV ; EQFMKLYEEK ; TGNAWHSKNF ; TKYPKKFYPL ; EIDYGQDEEA ; 700: VKKLTVKPGT ; KSKLPKPVQE ; LVGMIFDVDS ; MKKALVEYEI ; DLQKMPLGKL ; 750: SRRQIQAAYS ; ILSEVQQPVS ; QGSSESQILD ; LSNRFYTLIP ; HDFGMKKPPL ; 800: LNNADSVQAK ; VEMLDNLLDI ; EVAYSLLRGG ; SDDSSKDPID ; VNYEKLKTDI ; 850: KVVDRDSEEA ; EVIRKYVKNT ; HATTHNAYDL ; EVIDIFKIER ; EGESQRYKPF ; 900: RQLHNRRLLW ; HGSRTTNFAG ; ILSQGLRIAP ; PEAPVTGYMF ; GKGIYFADMV ; 950: SKSANYCHTS ; QGDPIGLIML ; GEVALGNMYE ; LKHASHISKL ; PKGKHSVKGL ; 1000: GKTTPDPSAS ; ITLEGVEVPL ; GTGIPSGVND ; TALLYNEYIV ; YDIAQVNLKY ; 1013: LLKLKFNFKT ; SLW
Sequence Length	1013
String	P11103
Sub Unit	Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LRIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY Interacts (when poly-ADP-ribosylated) with CHD1L. Interacts with the DNA polymerase alpha catalytic subunit POLA1; this interaction functions as part of the control of replication fork progression (By similarity). The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423. Interacts with RNF4. Interacts with EEF1A1 and TXK.

Uniprot	P11103
Gene Name	Parp1
Immunogen Species	Mus musculus (Mouse)
Unigene	Mm.277779

Reference	1. "Sequence and organization of the mouse poly (ADP-ribose) polymerase gene." Huppi K., Bhatia K., Siwarski D., Klinman D., Cherney B., Smulson M. Nucleic Acids Res.17:3387-3401(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) strain: BXSB. 2. "Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks." Sallmann F.R., Vodenicharov M.D., Wang Z.-Q., Poirier G.G. J. Biol. Chem.275:15504-15511(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);CHARACTERIZATION strain: C57BL/6 X 129/Sv. tissue: Fibroblast. 3. "A B-cell-specific DNA recombination complex." Borggrefe T., Wabl M., Akhmedov A.T., Jessberger R. J. Biol. Chem.273:17025-17035(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 109-119 AND 865-875;SUBUNIT;TISSUE SPECIFICITY strain: C57BL/6. tissue: Spleen. 4. "On the biological role of the nuclear polymerizing NAD+: protein(ADP-ribosyl) transferase (ADPRT): ADPRT from Dictyostelium discoideum and inactivation of the ADPRT gene in the mouse." Auer B., Flick K., Wang Z.Q., Haidacher D., Jaeger S., Berghammer H., Kofler B., Schweiger M., Wagner E.F. Biochimie77:444-449(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 5. "Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1." Schreiber V., Ame J.-C., Dolle P., Schultz I., Rinaldi B., Fraulob V., Menissier-de Murcia J., de Murcia G.M. J. Biol. Chem.277:23028-23036(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE 6. "Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes." Ku M.-C., Stewart S., Hata A. Biochem. Biophys. Res. Commun.311:702-707(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF423 7. "Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene." Yu Z., Kuncewicz T., Dubinsky W.P., Kone B.C. J. Biol. Chem.281:9101-9109(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION 8. "Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation." Takefuji M., Mori K., Morita Y., Arimura N., Nishimura T., Nakayama M., Hoshino M., Iwamatsu A., Murohara T., Kaibuchi K., Amano M. Biochem. Biophys. Res. Commun.355:788-794(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TIAM2 9. "PARP-1 transcriptional activity is regulated by sumoylation upon heat shock." Martin N., Schwamborn K., Schreiber V., Werner A., Guillier C., Zhang X.D., Bischof O., Seeler J.S., Dejean A. EMBO J.28:3534-3548(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF4 10. "Poly(ADP-ribose)-dependent regulation of Snail1 protein stability." Rodriguez M.I., Gonzalez-Flores A., Dantzer F., Collard J., de Herreros A.G., Oliver F.J. Oncogene30:4365-4372(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNAI1 11. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways." Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y. Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-97;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Embryonic fibroblast.

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