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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Pleckstrin homology domain-containing family O member 1

SKU : BHE13808658

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15005m
Categories	Elisa
Function	Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Specificity	Natural and recombinant Mouse Pleckstrin homology domain-containing family O member 1
Subcellular Location	Membrane Nucleus Cytoplasm
Detection Range	0.156-10ng/mL
Entryname	PKHO1_MOUSE
Method Type	Sandwich
Platform	PF00169
Protein Name	Pleckstrin homology domain-containing family O member 1
Sensitivity	0.086ng/mL
Sequence	50: MKKSGSGKRG ; PPDGNHQSAA ; PEKVGWVRKF ; CGKGIFREIW ; KNRYVVLKGD ; 100: QLYVSEKEVK ; DEKNSQEVFD ; LSDYEKCEEL ; RKSKSRSKKN ; HSKFTLARCR ; 150: QPGTTAPNLI ; FLAVSPEEKE ; SWINALSSAI ; TRAKNRILDE ; VTVEEDSYLA ; 200: HPTRDRAKIQ ; HSRRPPTRGH ; LMAVASTSTS ; DGMLTLDLIQ ; EEDPSPEEPA ; 250: SCAESFRVDL ; DKSVAQLAGS ; RRRADSDRIQ ; PSSQRASSLS ; RPWEKPDKGA ; 300: PYTPQALKKF ; PSTEKSRCAS ; LEEILSQRDT ; APARPLHLQA ; EESLPPVPAQ ; 350: PGQLSRIQDL ; VARKLEKTQE ; LLAEVQGLGD ; GKRKAKDPPQ ; SPPDSESEQL ; 400: LLETERLLGE ; ASSNWSQAKR ; VLQEVRELRD ; LYRQMDLQTP ; DSHLRQTSQH ; 408: SQYRKSLM
Sequence Length	408
String	Q9JIY0
Sub Unit	Heterodimer or homodimer. Interacts with CK2 and actin capping subunits (capping protein CP-alpha and CP-beta). CKIP1 and CK2 together inhibit the activity of actin capping protein at the barbed ends of actin filaments. Interacts with ATM, IFP35, JUN, JUND, NMI and PI3K. Interacts with AKT1, AKT2 and AKT3 (each isozyme of PKB), PtdIns(3,5)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P2.

Uniprot	Q9JIY0
Gene Name	Plekho1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:67220
Unigene	Mm.458147

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808658	E15005m	96T	$776		Add to Cart

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