Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Plays a crucial role in fetal and adult hematopoiesis, and normal prenatal and postnatal growth and viability.
Specificity
Natural and recombinant Mouse Phosphatidylinositol-binding clathrin assembly protein
Subcellular Location
Membrane clathrin-coated pit Golgi apparatus Cytoplasmic vesicle clathrin-coated vesicle Colocalized with clathrin in the Golgi area.