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ELISA Kit for Mouse Peroxisome proliferator-activated receptor alpha

SKU : BHE13808989

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0934m
Alternative Names	Nuclear receptor subfamily 1 group C member 1 ; Nr1c1 ; Ppar
Categories	Elisa
Function	Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.
Specificity	Natural and recombinant Mouse Peroxisome proliferator-activated receptor alpha
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	PPARA_MOUSE
Method Type	Sandwich
Platform	PF00104
Protein Name	Peroxisome proliferator-activated receptor alpha
Sensitivity	0.078ng/mL
Sequence	50: MVDTESPICP ; LSPLEADDLE ; SPLSEEFLQE ; MGNIQEISQS ; IGEESSGSFG ; 100: FADYQYLGSC ; PGSEGSVITD ; TLSPASSPSS ; VSCPVIPAST ; DESPGSALNI ; 150: ECRICGDKAS ; GYHYGVHACE ; GCKGFFRRTI ; RLKLVYDKCD ; RSCKIQKKNR ; 200: NKCQYCRFHK ; CLSVGMSHNA ; IRFGRMPRSE ; KAKLKAEILT ; CEHDLKDSET ; 250: ADLKSLGKRI ; HEAYLKNFNM ; NKVKARVILA ; GKTSNNPPFV ; IHDMETLCMA ; 300: EKTLVAKMVA ; NGVEDKEAEV ; RFFHCCQCMS ; VETVTELTEF ; AKAIPGFANL ; 350: DLNDQVTLLK ; YGVYEAIFTM ; LSSLMNKDGM ; LIAYGNGFIT ; REFLKNLRKP ; 400: FCDIMEPKFD ; FAMKFNALEL ; DDSDISLFVA ; AIICCGDRPG ; LLNIGYIEKL ; 450: QEGIVHVLKL ; HLQSNHPDDT ; FLFPKLLQKM ; VDLRQLVTEH ; AQLVQVIKKT ; 468: ESDAALHPLL ; QEIYRDMY
Sequence Length	468
String	P23204
Sub Unit	Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity (By similarity). Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6.

Uniprot	P23204
Gene Name	Ppara
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:19013
Unigene	Mm.212789

Reference	1. "Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators." Issemann I., Green S. Nature347:645-650(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Structure of the mouse peroxisome proliferator activated receptor alpha gene." Gearing K.L., Crickmore A., Gustafsson J.-A. Biochem. Biophys. Res. Commun.199:255-263(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] strain: 129/Sv. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: FVB/N. tissue: Kidney. 4. "Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes." Jones P.S., Savory R., Barratt P., Bell A.R., Gray T.J.B., Jenkins N.A., Gilbert D.J., Copeland N.G., Bell D.R. Eur. J. Biochem.233:219-226(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 413-468 strain: Swiss Webster. tissue: Liver. 5. "Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor." Zhu Y., Qi C., Jain S., Rao M.S., Reddy J.K. J. Biol. Chem.272:25500-25506(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPARBP 6. "Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action." Rubino D., Driggers P., Arbit D., Kemp L., Miller B., Coso O., Pagliai K., Gray K., Gutkind S., Segars J. Oncogene16:2513-2526(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKAP13 7. "Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR." Zhu Y.-J., Kan L., Qi C., Kanwar Y.S., Yeldandi A.V., Rao M.S., Reddy J.K. J. Biol. Chem.275:13510-13516(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6 8. "Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha." Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez De Fonseca F., Rosengarth A., Luecke H., Di Giacomo B., Tarzia G., Piomelli D. Nature425:90-93(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS RECEPTOR FOR OLEYLETHANOLAMIDE;FUNCTION 9. "Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway." Finck B.N., Gropler M.C., Chen Z., Leone T.C., Croce M.A., Harris T.E., Lawrence J.C. Jr., Kelly D.P. Cell Metab.4:199-210(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIPN1 10. "PRDM16 controls a brown fat/skeletal muscle switch." Seale P., Bjork B., Yang W., Kajimura S., Chin S., Kuang S., Scime A., Devarakonda S., Conroe H.M., Erdjument-Bromage H., Tempst P., Rudnicki M.A., Beier D.R., Spiegelman B.M. Nature454:961-967(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRDM16 11. "Identification of a physiologically relevant endogenous ligand for PPARalpha in liver." Chakravarthy M.V., Lodhi I.J., Yin L., Malapaka R.R., Xu H.E., Turk J., Semenkovich C.F. Cell138:476-488(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF 1-PALMITOYL-2-OLEOYL-SN-GLYCEROL-3-PHOSPHOCHOLINE AS A PHYSIOLOGICAL LIGAND;DNA-BINDING;FUNCTION;MUTAGENESIS OF CYS-119 AND CYS-122 12. "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors." Schmutz I., Ripperger J.A., Baeriswyl-Aebischer S., Albrecht U. Genes Dev.24:345-357(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CIRCADIAN RHYTHMS;INTERACTION WITH PER2;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-292 AND 459-LEU--TYR-468

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