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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse P-selectin glycoprotein ligand 1

SKU : BHE13810086

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9106m
Alternative Names	Selectin P ligand ; CD162 ; Selp1 ; Selpl
Categories	Elisa
Function	A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.
Specificity	Natural and recombinant Mouse P-selectin glycoprotein ligand 1
Subcellular Location	Cell membrane Single-pass membrane protein
Entryname	SELPL_MOUSE
Protein Name	P-selectin glycoprotein ligand 1
Sequence	50: MSPSFLVLLT ; ILGPGNSLQL ; QDPWGHETKE ; APGPVHLRER ; RQVVGDDDFE ; 100: DPDYTYNTDP ; PELLKNVTNT ; VAAHPELPTT ; VVMLERDSTS ; AGTSERATEK ; 150: IATTDPTAPG ; TGGTAVGMLS ; TDSATQWSLT ; SVETVQPAST ; EVETSQPAPM ; 200: EAETSQPAPM ; EAETSQPAPM ; EAETSQPAPM ; EADTSQPAPM ; EAETSQPAPN ; 250: EAETSKPAPT ; EAETSKPAPT ; EAETTQLPRI ; QAVKTLFTTS ; AATEVPSTEP ; 300: TTMETASTES ; NESTIFLGPS ; VTHLPDSGLK ; KGLIVTPGNS ; PAPTLPGSSD ; 350: LIPVKQCLLI ; ILILASLATI ; FLVCTVVLAV ; RLSRKTHMYP ; VRNYSPTEMI ; 397: CISSLLPEGG ; DGAPVTANGG ; LPKVQDLKTE ; PSGDRDGDDL ; TLHSFLP
Sequence Length	397
String	Q62170
Sub Unit	Homodimer; disulfide-linked. Interacts with P- and E-selectins, through their lectin/EGF domains. Interaction with P-selectin requires sialyl Lewis X glycan modification and tyrosine sulfation, probably on Tyr-54, for high affinity binding (By similarity). Dimerization appears not to be required for P-selectin/SELP binding (By similarity). Interacts with SNX20.

Uniprot	Q62170
Gene Name	Selplg
Immunogen Species	Mus musculus (Mouse)
Unigene	Mm.332590

Reference	1. "Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor." Yang J., Galipeau J., Kozak C., Furie B.C., Furie B. Blood87:4176-4186(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];INTERACTION WITH SELE AND SELP;TISSUE SPECIFICITY strain: BALB/c. 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. "P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration." Hirata T., Merrill-Skoloff G., Aab M., Yang J., Furie B.C., Furie B. J. Exp. Med.192:1669-1676(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELE AND SELP;FUNCTION 4. "P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin." Hirata T., Furie B.C., Furie B. J. Immunol.169:4307-4313(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 5. "N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin." Xia L., Ramachandran V., McDaniel J.M., Nguyen K.N., Cummings R.D., McEver R.P. Blood101:552-559(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELP;SULFATION;MUTAGENESIS OF TYR-54; THR-55; TYR-56 AND THR-58 6. "Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44." Hidalgo A., Peired A.J., Wild M.K., Vestweber D., Frenette P.S. Immunity26:477-489(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 7. "The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810086	E9106m	96T	$776		Add to Cart

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