ELISA Kit for Mouse Nuclear receptor ROR-gamma

Mfr.No.

E10640m

Alternative Names

Nuclear receptor RZR-gamma ; Nuclear receptor subfamily 1 group F member 3 ; RAR-related orphan receptor C ; Retinoid-related orphan receptor-gamma ; Thymus orphan receptor ; TOR ; Nr1f3 ; Rorg ; Thor

Categories

Elisa

Function

Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T helper cells into Th17 cells. Regulate the expression of several components of the circadian clock (By similarity). Isoform 2 negatively regulates expression of TNFSF6/FASL and IL2 production in T-cells. It also binds to the TEA promoter and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus.

Specificity

Natural and recombinant Mouse Nuclear receptor ROR-gamma

Subcellular Location

Nucleus

Detection Range

0.156-10ng/mL

Entryname

RORG_MOUSE

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
EDTA plasma(n=5)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

Method Type

Sandwich

Platform

PF00104

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

Protein Name

Nuclear receptor ROR-gamma

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

Sensitivity

0.081ng/mL

Sequence

50:

MDRAPQRHHR ; TSRELLAAKK ; THTSQIEVIP ; CKICGDKSSG ; IHYGVITCEG ;

100:

CKGFFRRSQQ ; CNVAYSCTRQ ; QNCPIDRTSR ; NRCQHCRLQK ; CLALGMSRDA ;

150:

VKFGRMSKKQ ; RDSLHAEVQK ; QLQQQQQQEQ ; VAKTPPAGSR ; GADTLTYTLG ;

200:

LSDGQLPLGA ; SPDLPEASAC ; PPGLLRASGS ; GPPYSNTLAK ; TEVQGASCHL ;

250:

EYSPERGKAE ; GRDSIYSTDG ; QLTLGRCGLR ; FEETRHPELG ; EPEQGPDSHC ;

300:

IPSFCSAPEV ; PYASLTDIEY ; LVQNVCKSFR ; ETCQLRLEDL ; LRQRTNLFSR ;

350:

EEVTSYQRKS ; MWEMWERCAH ; HLTEAIQYVV ; EFAKRLSGFM ; ELCQNDQIIL ;

400:

LTAGAMEVVL ; VRMCRAYNAN ; NHTVFFEGKY ; GGVELFRALG ; CSELISSIFD ;

450:

FSHFLSALCF ; SEDEIALYTA ; LVLINANRPG ; LQEKRRVEHL ; QYNLELAFHH ;

500:

HLCKTHRQGL ; LAKLPPKGKL ; RSLCSQHVEK ; LQIFQHLHPI ; VVQAAFPPLY ;

516:

KELFSTDVES ; PEGLSK

Sequence Length

516

String

P51450

Uniprot	P51450
Gene Name	Rorc
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:19885
Unigene	Mm.4372

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BHE13809818	E10640m	96T	$776		Add to Cart

ELISA Kit for Mouse Nuclear receptor ROR-gamma

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