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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse NF-kappa-B inhibitor alpha

SKU : BHE13805681

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1848m
Alternative Names	I-kappa-B-alpha ; IkB-alpha ; Ikba
Categories	Elisa
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
Specificity	Natural and recombinant Mouse NF-kappa-B inhibitor alpha
Subcellular Location	Cytoplasm Nucleus Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Detection Range	0.312-20ng/mL
Entryname	IKBA_MOUSE
Method Type	Sandwich
Platform	PF12796
Protein Name	NF-kappa-B inhibitor alpha
Sensitivity	0.183ng/mL
Sequence	50: MFQPAGHGQD ; WAMEGPRDGL ; KKERLVDDRH ; DSGLDSMKDE ; EYEQMVKELR ; 100: EIRLQPQEAP ; LAAEPWKQQL ; TEDGDSFLHL ; AIIHEEKPLT ; MEVIGQVKGD ; 150: LAFLNFQNNL ; QQTPLHLAVI ; TNQPGIAEAL ; LKAGCDPELR ; DFRGNTPLHL ; 200: ACEQGCLASV ; AVLTQTCTPQ ; HLHSVLQATN ; YNGHTCLHLA ; SIHGYLAIVE ; 250: HLVTLGADVN ; AQEPCNGRTA ; LHLAVDLQNP ; DLVSLLLKCG ; ADVNRVTYQG ; 300: YSPYQLTWGR ; PSTRIQQQLG ; QLTLENLQML ; PESEDEESYD ; TESEFTEDEL ; 314: PYDDCVFGGQ ; RLTL
Sequence Length	314
String	Q9Z1E3
Sub Unit	Interacts with PRMT2 (By similarity). Interacts with RELA; the interaction requires the nuclear import signal. Interacts with NKIRAS1 and NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HBV protein X. Interacts with RWDD3; the interaction enhances sumoylation. Interacts (when phosphorylated at the 2 serine residues in the destruction motif D-S-G-X(2,3,4)-S) with BTRC. Associates with the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC; the association is mediated via interaction with BTRC. Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with RELA; RELA interacts directly with NFKBIA.

Uniprot	Q9Z1E3
Gene Name	Nfkbia
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:18035
Unigene	Mm.170515

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805681	E1848m	96T	$776		Add to Cart

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