NK cell type I receptor protein 2B4 ; NKR2B4 ; Non-MHC restricted killing associated ; SLAM family member 4 ; SLAMF4 ; Signaling lymphocytic activation molecule 4 ; CD244 ; 2b4 ; Nmrk
Categories
Elisa
Function
Modulate other receptor-ligand interactions to enhance leukocyte activation.
Specificity
Natural and recombinant Mouse Natural killer cell receptor 2B4
Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2.