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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse NAD-dependent deacetylase sirtuin-1

SKU : BHE13809579

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3949m
Alternative Names	SIR2-like protein 1 ; SIR2alpha ; Sir2 ; mSIR2a ; Sir2l1
Categories	Elisa
Function	NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. Deacetylates 'Lys-16' of histone H4 (in vitro). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Deacetylates APEX1 at 'Lys-6' and 'Lys-7'. Stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (By similarity). Essential during embryogenesis and gametogenesis. Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. Deacetylates 'Lys-266' of SUV39H1, leading to its activation. Deacetylates 'Lys-26' of HIST1H1E. Deacetylates H2A. Involved in HES1- and HEY2-mediated transcriptional repression. Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. May serve as a sensor of the cytosolic ratio of NAD(+)/NADH, which is essential in skeletal muscle cell differentiation.
Specificity	Natural and recombinant Mouse NAD-dependent deacetylase sirtuin-1
Subcellular Location	Nucleus PML body Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane.
Detection Range	31.2-2000pg/mL
Entryname	SIRT1_MOUSE
Method Type	Sandwich
Platform	PF02146
Protein Name	NAD-dependent deacetylase sirtuin-1
Sensitivity	15.68pg/mL
Sequence	50: MADEVALALQ ; AAGSPSAAAA ; MEAASQPADE ; PLRKRPRRDG ; PGLGRSPGEP ; 100: SAAVAPAAAG ; CEAASAAAPA ; ALWREAAGAA ; ASAEREAPAT ; AVAGDGDNGS ; 150: GLRREPRAAD ; DFDDDEGEEE ; DEAAAAAAAA ; AIGYRDNLLL ; TDGLLTNGFH ; 200: SCESDDDDRT ; SHASSSDWTP ; RPRIGPYTFV ; QQHLMIGTDP ; RTILKDLLPE ; 250: TIPPPELDDM ; TLWQIVINIL ; SEPPKRKKRK ; DINTIEDAVK ; LLQECKKIIV ; 300: LTGAGVSVSC ; GIPDFRSRDG ; IYARLAVDFP ; DLPDPQAMFD ; IEYFRKDPRP ; 350: FFKFAKEIYP ; GQFQPSLCHK ; FIALSDKEGK ; LLRNYTQNID ; TLEQVAGIQR ; 400: ILQCHGSFAT ; ASCLICKYKV ; DCEAVRGDIF ; NQVVPRCPRC ; PADEPLAIMK ; 450: PEIVFFGENL ; PEQFHRAMKY ; DKDEVDLLIV ; IGSSLKVRPV ; ALIPSSIPHE ; 500: VPQILINREP ; LPHLHFDVEL ; LGDCDVIINE ; LCHRLGGEYA ; KLCCNPVKLS ; 550: EITEKPPRPQ ; KELVHLSELP ; PTPLHISEDS ; SSPERTVPQD ; SSVIATLVDQ ; 600: ATNNNVNDLE ; VSESSCVEEK ; PQEVQTSRNV ; ENINVENPDF ; KAVGSSTADK ; 650: NERTSVAETV ; RKCWPNRLAK ; EQISKRLEGN ; QYLFVPPNRY ; IFHGAEVYSD ; 700: SEDDVLSSSS ; CGSNSDSGTC ; QSPSLEEPLE ; DESEIEEFYN ; GLEDDTERPE ; 737: CAGGSGFGAD ; GGDQEVVNEA ; IATRQELTDV ; NYPSDKS
Sequence Length	737
String	Q923E4
Sub Unit	Interacts with MLLT7/FOXO4, HES1, HEY2, PML and RPS19BP1/AROS. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. Interacts with KIAA1967/DBC1 (via N-terminus). Interacts with APEX1; the interaction is promoted in the context of genotoxic stress (By similarity). Found in a complex with PCAF and MYOD1. Interacts with p53/TP53. Interacts with TAF1B. Interacts with FOXO1 and this interaction requires the presence of KRIT1. Interacts with STK4/MST1.

Uniprot	Q923E4
Gene Name	SIRT1
Kegg	mmu:93759
Unigene	Mm.351459

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809579	E3949m	96T	$776		Add to Cart

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