Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR.
Specificity
Natural and recombinant Mouse Myoferlin
Subcellular Location
Cell membrane Single-pass type II membrane protein Nucleus membrane Single-pass type II membrane protein Cytoplasmic vesicle membrane Single-pass type II membrane protein Found at nuclear and plasma membranes. Enriched in undifferentiated myoblasts near the plasma membrane in puncate structures (By similarity). Concentrated at the membrane sites of both myoblast-myoblast and myoblast-myotube fusions. Detected at the plasmalemma in endothelial cells lining intact blood vessels.