Basic SAP coiled-coil transcription activator 2 ; SRF cofactor protein ; Bsac2 ; Mycd ; Srfcp
Categories
Elisa
Function
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.
Specificity
Natural and recombinant Mouse Myocardin
Subcellular Location
Nucleus speckle Nuclear, with a punctate intranuclear patte with exclusion from nuclei.
Homodimer. Interacts with MLLT7/FOXO4 (By similarity). Interacts with SRF, its association does not depend on specific DNA sequences for teary complex formation. Interacts (via C-terminal) with EP300 (via CREB-binding domain). Interacts with HDAC4 and HDAC5. Interacts with MEF2C.