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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Mothers against decapentaplegic homolog 6

SKU : BHE13810188

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2187m
Alternative Names	Mad homolog 7 ; SMAD family member 6 ; SMAD 6 ; Madh6 ; Madh7 ; Msmad6
Categories	Elisa
Function	Binds to regulatory elements in target promoter regions (By similarity). Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Inhibits phosphorylation activity of SMAD1 induced by BMP type IB receptor and interferes with the phosphorylation of SMAD2 and the subsequent heteromerization with SMAD4.
Specificity	Natural and recombinant Mouse Mothers against decapentaplegic homolog 6
Subcellular Location	Nucleus
Detection Range	15.6-1000pg/mL
Entryname	SMAD6_MOUSE
Method Type	Sandwich
Platform	PF03165
Protein Name	Mothers against decapentaplegic homolog 6
Sensitivity	4.4pg/mL
Sequence	50: MFRSKRSGLV ; RRLWRSRVVP ; DREEGSGGGG ; GVDEDGSLGS ; RAEPAPRARE ; 100: GGGCSRSEVR ; SVAPRRPRDA ; VGPRGAAIAG ; RRRRTGGLPR ; PVSESGAGAG ; 150: GSPLDVAEPG ; GPGWLPESDC ; ETVTCCLFSE ; RDAAGAPRDS ; GDPQARQSPE ; 200: PEEGGGPRSR ; EARSRLLLLE ; QELKTVTYSL ; LKRLKERSLD ; TLLEAVESRG ; 250: GVPGGCVLVP ; RADLRLGGQP ; APPQLLLGRL ; FRWPDLQHAV ; ELKPLCGCHS ; 300: FTAAADGPTV ; CCNPYHFSRL ; CGPESPPPPY ; SRLSPPDQYK ; PLDLSDSTLS ; 350: YTETEATNSL ; ITAPGEFSDA ; SMSPDATKPS ; HWCSVAYWEH ; RTRVGRLYAV ; 400: YDQAVSIFYD ; LPQGSGFCLG ; QLNLEQRSES ; VRRTRSKIGF ; GILLSKEPDG ; 450: VWAYNRGEHP ; IFVNSPTLDA ; PGGRALVVRK ; VPPGYSIKVF ; DFERSGLLQH ; 495: ADAAHGPYDP ; HSVRISFAKG ; WGPCYSRQFI ; TSCPCWLEIL ; LNNHR
Sequence Length	495
String	O35182
Sub Unit	Interacts with STAMBP and PRKX (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members. Interacts with NEDD4L. Interacts with WWP1.

Uniprot	O35182
Gene Name	Smad6
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:17130
Unigene	Mm.325757

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810188	E2187m	96T	$776		Add to Cart

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