Dwarfin-C ; Dwf-C ; SMAD family member 5 ; SMAD 5 ; Madh5 ; Msmad5
Categories
Elisa
Function
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity). Required for angiogenesis.
Specificity
Natural and recombinant Mouse Mothers against decapentaplegic homolog 5
Subcellular Location
Cytoplasm Nucleus In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4.
May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3 (By similarity). Interacts with WWP1.