Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.
Specificity
Natural and recombinant Mouse Melanocortin receptor 4
Interacts with ATRNL1. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.