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ELISA Kit for Mouse Low-density lipoprotein receptor-related protein 8

SKU : BHE13806374

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10006m
Alternative Names	Apolipoprotein E receptor 2 ; Apoer2
Categories	Elisa
Function	Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
Specificity	Natural and recombinant Mouse Low-density lipoprotein receptor-related protein 8
Subcellular Location	Cell membrane Single-pass type I membrane protein Secreted Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.
Detection Range	0.312-20ng/ml
Entryname	LRP8_MOUSE
Method Type	Sandwich
Platform	PF07645
Protein Name	Low-density lipoprotein receptor-related protein 8
Sensitivity	0.158ng/mL
Sequence	50: MGRPELGALR ; PLALLLLLLL ; QLQHLSAADP ; LPGGQGPVKE ; CEEDQFRCRN ; 100: ERCIPLVWRC ; DEDNDCSDNS ; DEDDCPKRTC ; ADSDFTCDNG ; HCIPERWKCD ; 150: GEEECPDGSD ; ESKATCSSEE ; CPAEKLSCGP ; TSHKCVPASW ; RCDGEKDCEG ; 200: GADEAGCPTL ; CAPHEFQCSN ; RSCLASVFVC ; DGDDDCGDGS ; DERGCSDPAC ; 250: PPREFRCGGG ; GTCIPERWVC ; DRQFDCEDRS ; DEAAELCGRA ; GQGTTATPAA ; 300: CAPTAQFTCR ; SGECIHLGWR ; CDGDRDCKDK ; SDEADCSPGP ; CRENEFQCGD ; 350: GTCVLAIKRC ; NQERDCPDGS ; DEAGCLQEST ; CEGPRRFQCK ; SGECVDGGKV ; 400: CDDQRDCRDW ; SDEPQKVCGL ; NECLHNNGGC ; SHICTDLKIG ; FECTCPAGFQ ; 450: LLDQKTCGDI ; DECQDPDACS ; QICVNYKGYF ; KCECHPGYEM ; DTLTKNCKAV ; 500: AGKSPSLIFT ; NRHEVRRIDL ; VKRDYSRLIP ; MLKNVVALDV ; EVATNRIYWC ; 550: DLSYRKIYSA ; HMDKASIPDE ; QVVLIDEQLH ; SPEGLAVDWV ; HKHIYWTDSG ; 600: NKTISVATTD ; GRRRCTLFSR ; ELSEPRAIAV ; DPLRGFMYWS ; DWGFQAKIEK ; 650: AGLNGADRQT ; LVSDNIEWPN ; GITLDLLSQR ; LYWVDSKLHQ ; LSSIDFNGGN ; 700: RKMLIFSTDF ; LSHPFGVAVF ; EDKVFWTDLE ; NEAIFSANRL ; NGLEIAILAE ; 750: NLNNPHDIVI ; FHELKQPKAA ; DACDLSAQPN ; GGCEYLCLPA ; PQISSHSPKY ; 800: TCACPDTMWL ; GPDMKRCYRA ; PQSTSTTTLA ; SAMTRTVPAT ; TRAPGTTIHD ; 850: PTYQNHSTET ; PSQTAAAPHS ; VNVPRAPSTS ; PSTPSPATSN ; HSQHYGNEGS ; 900: QMGSTVTAAV ; IGVIVPIVVI ; ALLCMSGYLI ; WRNWKRKNTK ; SMNFDNPVYR ; 950: KTTEEEEEDE ; LHIGRTAQIG ; HVYPAAISNY ; DRPLWAEPCL ; GETRDLEDPA ; 996: PALKELFVLP ; GEPRSQLHQL ; PKNPLSELPV ; VKCKRVALSL ; EDDGLP
Sequence Length	996
String	Q924X6
Sub Unit	Reelin associates with two or more receptor molecules. Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17.

Uniprot	Q924X6
Gene Name	Lrp8
Immunogen Species	Mus musculus (Mouse)
Unigene	Mm.442134

Reference	1. "Evolution of the apolipoprotein E receptor 2 gene by exon loss." Kim H.-J., Kim D.-H., Magoori K., Saeki S., Yamamoto T. J. Biochem.124:451-456(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) tissue: Brain. 2. "Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha2-macroglobulin." Brandes C., Kahr L., Stockinger W., Hiesberger T., Schneider W.J., Nimpf J. J. Biol. Chem.276:22160-22169(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING;INTERACTION WITH REELIN AND ALPHA2-MACROGLOBULIN 3. "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor." Stockinger W., Sailler B., Strasser V., Recheis B., Fasching D., Kahr L., Schneider W.J., Nimpf J. EMBO J.21:4259-4267(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX17 4. "Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase." May P., Bock H.H., Nimpf J., Herz J. J. Biol. Chem.278:37386-37392(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;GLYCOSYLATION;PROTEOLYTIC PROCESSING 5. "A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling." Koch S., Strasser V., Hauser C., Fasching D., Brandes C., Bajari T.M., Schneider W.J., Nimpf J. EMBO J.21:5996-6004(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;PROTEOLYTIC PROCESSING 6. "Essential role of the apolipoprotein E receptor-2 in sperm development." Andersen O.M., Yeung C.H., Vorum H., Wellner M., Andreassen T.K., Erdmann B., Mueller E.C., Herz J., Otto A., Cooper T.G., Willnow T.E. J. Biol. Chem.278:23989-23995(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SPERM DEVELOPMENT 7. "Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2." Trommsdorff M., Gotthardt M., Hiesberger T., Shelton J., Stockinger W., Nimpf J., Hammer R.E., Richardson J.A., Herz J. Cell97:689-701(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB1 8. "The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2." Stockinger W., Brandes C., Fasching D., Hermann M., Gotthardt M., Herz J., Schneider W.J., Nimpf J. J. Biol. Chem.275:25625-25632(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JNK-INTERACTING PROTEINS;TISSUE SPECIFICITY 9. "Differential binding of ligands to the apolipoprotein E receptor 2." Andersen O.M., Benhayon D., Curran T., Willnow T.E. Biochemistry42:9355-9364(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAP AND REELIN;STOICHIOMETRY;MUTAGENESIS

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