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ELISA Kit for Mouse Low-density lipoprotein receptor-related protein 5

SKU : BHE13806344

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3681m
Alternative Names	Low-density lipoprotein receptor-related protein 7 ; LRP-7 ; Lr3 ; Lrp7
Categories	Elisa
Function	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (By similarity). Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
Specificity	Natural and recombinant Mouse Low-density lipoprotein receptor-related protein 5
Subcellular Location	Membrane Single-pass type I membrane protein Endoplasmic reticulum Chaperoned to the plasma membrane by MESD.
Detection Range	78-5000pg/mL
Entryname	LRP5_MOUSE
Method Type	Sandwich
Platform	PF00057
Protein Name	Low-density lipoprotein receptor-related protein 5
Sensitivity	40pg/mL
Sequence	50: METAPTRAPP ; PPPPPLLLLV ; LYCSLVPAAA ; SPLLLFANRR ; DVRLVDAGGV ; 100: KLESTIVASG ; LEDAAAVDFQ ; FSKGAVYWTD ; VSEEAIKQTY ; LNQTGAAAQN ; 150: IVISGLVSPD ; GLACDWVGKK ; LYWTDSETNR ; IEVANLNGTS ; RKVLFWQDLD ; 200: QPRAIALDPA ; HGYMYWTDWG ; EAPRIERAGM ; DGSTRKIIVD ; SDIYWPNGLT ; 250: IDLEEQKLYW ; ADAKLSFIHR ; ANLDGSFRQK ; VVEGSLTHPF ; ALTLSGDTLY ; 300: WTDWQTRSIH ; ACNKWTGEQR ; KEILSALYSP ; MDIQVLSQER ; QPPFHTPCEE ; 350: DNGGCSHLCL ; LSPREPFYSC ; ACPTGVQLQD ; NGKTCKTGAE ; EVLLLARRTD ; 400: LRRISLDTPD ; FTDIVLQVGD ; IRHAIAIDYD ; PLEGYVYWTD ; DEVRAIRRAY ; 450: LDGSGAQTLV ; NTEINDPDGI ; AVDWVARNLY ; WTDTGTDRIE ; VTRLNGTSRK ; 500: ILVSEDLDEP ; RAIVLHPVMG ; LMYWTDWGEN ; PKIECANLDG ; RDRHVLVNTS ; 550: LGWPNGLALD ; LQEGKLYWGD ; AKTDKIEVIN ; IDGTKRKTLL ; EDKLPHIFGF ; 600: TLLGDFIYWT ; DWQRRSIERV ; HKVKASRDVI ; IDQLPDLMGL ; KAVNVAKVVG ; 650: TNPCADGNGG ; CSHLCFFTPR ; ATKCGCPIGL ; ELLSDMKTCI ; IPEAFLVFTS ; 700: RATIHRISLE ; TNNNDVAIPL ; TGVKEASALD ; FDVSNNHIYW ; TDVSLKTISR ; 750: AFMNGSSVEH ; VIEFGLDYPE ; GMAVDWMGKN ; LYWADTGTNR ; IEVARLDGQF ; 800: RQVLVWRDLD ; NPRSLALDPT ; KGYIYWTEWG ; GKPRIVRAFM ; DGTNCMTLVD ; 850: KVGRANDLTI ; DYADQRLYWT ; DLDTNMIESS ; NMLGQERMVI ; ADDLPYPFGL ; 900: TQYSDYIYWT ; DWNLHSIERA ; DKTSGRNRTL ; IQGHLDFVMD ; ILVFHSSRQD ; 950: GLNDCVHSNG ; QCGQLCLAIP ; GGHRCGCASH ; YTLDPSSRNC ; SPPSTFLLFS ; 1000: QKFAISRMIP ; DDQLSPDLVL ; PLHGLRNVKA ; INYDPLDKFI ; YWVDGRQNIK ; 1050: RAKDDGTQPS ; MLTSPSQSLS ; PDRQPHDLSI ; DIYSRTLFWT ; CEATNTINVH ; 1100: RLDGDAMGVV ; LRGDRDKPRA ; IAVNAERGYM ; YFTNMQDHAA ; KIERASLDGT ; 1150: EREVLFTTGL ; IRPVALVVDN ; ALGKLFWVDA ; DLKRIESCDL ; SGANRLTLED ; 1200: ANIVQPVGLT ; VLGRHLYWID ; RQQQMIERVE ; KTTGDKRTRV ; QGRVTHLTGI ; 1250: HAVEEVSLEE ; FSAHPCARDN ; GGCSHICIAK ; GDGTPRCSCP ; VHLVLLQNLL ; 1300: TCGEPPTCSP ; DQFACTTGEI ; DCIPGAWRCD ; GFPECADQSD ; EEGCPVCSAS ; 1350: QFPCARGQCV ; DLRLRCDGEA ; DCQDRSDEAN ; CDAVCLPNQF ; RCTSGQCVLI ; 1400: KQQCDSFPDC ; ADGSDELMCE ; INKPPSDDIP ; AHSSAIGPVI ; GIILSLFVMG ; 1450: GVYFVCQRVM ; CQRYTGASGP ; FPHEYVGGAP ; HVPLNFIAPG ; GSQHGPFPGI ; 1500: PCSKSVMSSM ; SLVGGRGSVP ; LYDRNHVTGA ; SSSSSSSTKA ; TLYPPILNPP ; 1550: PSPATDPSLY ; NVDVFYSSGI ; PATARPYRPY ; VIRGMAPPTT ; PCSTDVCDSD ; 1600: YSTSRWKSSK ; YYLDLNSDSD ; PYPPPPTPHS ; QYLSAEDSCP ; PSPGTERSYC ; 1614: HLFPPPPSPC ; TDSS
Sequence Length	1614
String	Q91VN0
Sub Unit	Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Component of a WNT-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with FZD8; the interaction is formed on WNT-binding and signaling. Interacts (via the phosphorylated PPPSP motif domains) with AXIN1; the interaction prevents inhibition of beta-catenin phosphorylation and signaling and is enhanced in the presence of GSK3B and WNT1 or WNT3A. Interacts (via beta-propeller regions 3 and 4) with DKK1; the interaction, enhanced by MESD and/or KREMEN, inhibits beta-catenin signaling by preventing GSK3-mediated phosphorylation of the PPPSP motifs and subsequent, AXIN1 binding. Interacts with CSNK1E. Interacts with SOST; the interaction antagonizes canonical Wnt signaling. Interacts with APCDD1 (By similarity). Interacts with MESD; the interaction prevents the formation of LRP5 aggregates, targets LRP5 to the plasma membrane and, when complexed with KREMEN2, increases DKK1 binding.

Uniprot	Q91VN0
Gene Name	Lrp5
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16973
Unigene	Mm.274581

Reference	1. "Cloning of a novel member of the low-density lipoprotein receptor family." Hey P.J., Twells R.C.J., Phillips M.S., Nakagawa Y., Brown S.D., Kawaguchi Y., Cox R., Xie G., Dugan V., Hammond H., Metzker M.L., Todd J.A., Hess J.F. Gene216:103-111(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) tissue: Liver. 2. "Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human." Chen D., Lathrop W., Dong Y. Genomics55:314-321(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING tissue: Liver. 3. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) tissue: Mammary tumor. 5. "Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor." Kato M., Patel M.S., Levasseur R., Lobov I., Chang B.H., Glass D.A. II, Hartmann C., Li L., Hwang T.H., Brayton C.F., Lang R.A., Karsenty G., Chan L. J. Cell Biol.157:303-314(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION 6. "Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity." Hsieh J.-C., Lee L., Zhang L., Wefer S., Brown K., DeRossi C., Wines M.E., Rosenquist T., Holdener B.C. Cell112:355-367(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MESD;OLIGOMERIZATION;SUBCELLULAR LOCATION 7. "The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice." Kelly O.G., Pinson K.I., Skarnes W.C. Development131:2803-2815(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY

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