Cytokeratin endo B ; Keratin D ; Cytokeratin-18 ; CK-18 ; Keratin-18 ; K18 ; Kerd ; Krt1-18
Categories
Elisa
Function
When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Specificity
Natural and recombinant Mouse Keratin, type I cytoskeletal 18
Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with the thrombin-antithrombin complex. Interacts with DNAJB6, TCHP and TRADD.